Mutations that increase the affinity of the aop SAM domain for self-association have been introduced into the endogenous aop locus; the changes are R92K, A93E, G96R, and H97Y. Each mutation converts the wild-type aop residue to the equivalent residue found in the orthologous human ETV6 gene (HGNC:3495).
Dead aopSY5 embryos present defects in the anterior portion of the head cuticle. Adults show a rough eye phenotype; ommatidia show some extra photoreceptor cells, namely outer photoreceptor cells, and rare missing photoreceptor cells, as compared to controls.
