FlyBase Allele Report: Dmel\Panx[g1]

General Information

Symbol

Dmel\Panx^g1

Species

D. melanogaster

Name

FlyBase ID

FBal0345612

Feature type

allele

Associated gene

Dmel\Panx

Associated Insertion(s)

Carried in Construct

Also Known As

panx Δ_1-m3-4

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Sienski et al., 2015)

Mutagen

CRISPR/Cas9

(Sienski et al., 2015)

Progenitor genotype

Cytology

Description

Insertion/deletion mutation in the coding sequence close to the N-terminus, resulting in a frameshift.

(Sienski et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:21,312,041..21,312,047 [-]

Inserted_sequence:

AAAACGGG

Comment:

Seven base pairs (TCAAAGT) just downstream from the AUG are replaced with eight base pairs (AAAACGGG) causing a frameshift.

(Sienski et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage | female

(Sienski et al., 2015)

abnormal size | adult stage | female (with Panx^g2)

(Sienski et al., 2015)

decreased fecundity

(Sienski et al., 2015)

decreased fecundity (with Panx^g2)

(Sienski et al., 2015)

decreased fecundity | female (with Panx^g2)

(Batki et al., 2019)

female semi-fertile

(Sienski et al., 2015)

female sterile (with Panx^g2)

(Batki et al., 2019, Sienski et al., 2015)

female sterile | recessive

(Schnabl et al., 2021)

viable

(Sienski et al., 2015)

viable (with Panx^g2)

(Batki et al., 2019, Sienski et al., 2015)

Phenotype Manifest In

ovary | adult stage

(Sienski et al., 2015)

ovary | adult stage (with Panx^g2)

(Sienski et al., 2015)

Detailed Description

Statement

Reference

Panx^g1/Panx^g2 females develop gonads but are sterile, as they lay fewer eggs than Panx^g1/+ controls and none of these develop into a larva.

(Batki et al., 2019)

Panx^g1 homozygous and Panx^g1/Panx^g2 transheterozygous flies are viable but females exhibit oogenesis defects (i.e. smaller ovaries), and severe fertility defects.

(Sienski et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Panx^g1 is rescued by Panx^GFP

(Schnabl et al., 2021)

Partially rescued by

Panx^g1 is partially rescued by Panx^{ΔC-helix.GFP}

(Schnabl et al., 2021)

Panx^g1 is partially rescued by Panx^{ΔC-term-GCN4.GFP}

(Schnabl et al., 2021)

Panx^g1 is partially rescued by Panx^{ΔCtp-GCN4.GFP}

(Schnabl et al., 2021)

Not rescued by

Panx^g1 is not rescued by Panx^ΔC-term.GFP

(Schnabl et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG9754^g1

(Sienski et al., 2015)

CG9754^m3-4

(Teixeira et al., 2017)

Panx^g1

(Batki et al., 2019)

panx Δ_1-m3-4

(Schnabl et al., 2021, Batki et al., 2019)

panx^g1

(Andreev et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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