FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Su(dx)C917A.UAS.Tag:MYC
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General Information
Symbol
Dmel\Su(dx)C917A.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0345638
Feature type
allele
Associated gene
Dmel\Su(dx)
Associated Insertion(s)
Carried in Construct
P{UAS-Su(dx).C917A.MYC}
Key Links
Transgenic product class
dominant_negative_variant
(Li et al., 2018)
missense_variant
(Li et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Li et al., 2018)
missense_variant
(Li et al., 2018)
Mutagen
in vitro construct
(Li et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-Su(dx).C917A.MYC}
Cytology
Description

UASt regulatory sequences drive expression of a dominant negative form of Su(dx) that lacks its E3 ubiquitin ligase activity (C917A missense mutation), tagged with Tag:MYC at the N-terminus.

(Li et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Su(dx)
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  brain cancer
      modeled by Vps26HMS01769
      (Li et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Su(dx)C917A.UAS.Tag:MYC alone under the control of Scer\GAL4pnt-14-94 does not have a significant effect on the number of neuroblasts in the larval brain, as compared to controls.

      (Li et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(dx)C917A.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)