FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vps39Δ1
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General Information
Symbol
Dmel\Vps39Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0346048
Feature type
allele
Associated gene
Dmel\Vps39
Associated Insertion(s)
TI{TI}Vps39Δ1
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Lund et al., 2018)
Mutagen
CRISPR/Cas9
(Lund et al., 2018)
gene targeting by homologous recombination
(Lund et al., 2018)
Progenitor genotype
Associated Insertion(s)
TI{TI}Vps39Δ1
Cytology
Description

Most of the Vps39 coding sequence has been deleted (deletion coordinates 3R:18273942..18272027 ), allowing for expression of only the first 120 amino acid residues. A loxP cassette containing the Disc\RFPDsRed(T1).3xP3.cHa marker has been inserted in place of the deleted sequence.

(Lund et al., 2018)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:18,272,027..18,273,942 [-]
Comment:

1916bp of the Vps39 coding sequence has been deleted and replaced with a loxP cassette containing the Disc\RFPDsRed(T1).3xP3.cHa marker.

(Lund et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vps39Δ1/Df(3R)Exel6178 mutant larvae exhibit trafficking defects in the brain and Garland cells. In the brain, the lysosomal marker Lamp mislocalizes to cytoplasmic granules. In the Garland cells there are enlarged enlarged vacuoles and postendocytic trafficking defects (e.g. endocytozed proteins fail to be efficiently incorporated into Lysotracker-positive autolysosomes), as compared to controls.

      (Lund et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Vps39Δ1
      (Lund et al., 2021, Lund et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)