FB2026_02 , released June 18, 2026
Allele: Scer\GAL4C220
Open Close
General Information
Symbol
Scer\GAL4C220
Species
S. cerevisiae
Name
FlyBase ID
FBal0346383
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GAL4}C220
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GAL4}C220
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GAL4}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        adult taste projection neuron 3 | subset
        (Kim et al., 2017)
        neuron | subset of adult ventral nerve cord
        (Kim et al., 2017)
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Optogenetic activation (using Cnoc\ChR1Cs.IVS.20xUAS.Venus with 635 nm (red) light) of Scer\GAL4C220 neurons results in a significant reduction in proboscis extension reflex (PER) in response to 100 mM sucrose presentation, compared to controls; this aversion is sustained for several minutes after activation has finished.

        Inhibition (using shi1.UAS at 30[o]C) of Scer\GAL4C220 neurons does not affect PER in response to 100 mM sucrose, or a sweet and bitter mixture, compared to controls; it does significantly suppress the reduction in PER response to 100 mM sucrose seen during and after quinine application to the proboscis, compared to controls.

        (Kim et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4C220
        Name Synonyms
        Secondary FlyBase IDs
          References (1)