FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RyRG4946E
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General Information
Symbol
Dmel\RyRG4946E
Species
D. melanogaster
Name
FlyBase ID
FBal0346608
Feature type
allele
Associated gene
Dmel\RyR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Douris et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement equivalent to G4946E in the orthologous gene from Plutella xylostella. This variant is associated with resistance to diamide insecticides in Plutella xylostella.

(Douris et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2R:8,887,141..8,887,143 [+]
Nucleotide change:

GGC8887141GAG

Reported nucleotide change:

GC?AG

Reported amino acid change:

G?E

Comment:

Amino acid replacement equivalent to G4946E in the orthologous gene from Plutella xylostella. The second and third base of the codon are substituted (GGC to GAG).

(Douris et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RyRG4946E
      Name Synonyms
      Secondary FlyBase IDs
        References (1)