FlyBase Allele Report: Dmel\mir-279[ex117]

General Information

Symbol

Dmel\mir-279^ex117

Species

D. melanogaster

Name

FlyBase ID

FBal0346622

Feature type

allele

Associated gene

Dmel\mir-279

Associated Insertion(s)

Carried in Construct

Also Known As

mir-279^Δ1.2, ex117

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2014, Luo and Sehgal, 2012)

Mutagen

P-element activity

(Luo and Sehgal, 2012, Yoon et al., 2011, Cayirlioglu et al., 2008)

Progenitor genotype

P{EP}EP3626

(Cayirlioglu et al., 2008)

Cytology

Description

In addition to a lack of mir-279 expression, the mir-279[ex117] mutation also results in a reduction in mir-996 expression of more than 90% compared to controls.

(Sun et al., 2015)

Imprecise excision of an insertion, resulting in a 1.2kb deletion that removes mir-279.

(Luo and Sehgal, 2012)

Imprecise excision of P{EP}EP3626 generates a 1.2kb deletion that removes the mir-279 locus.

(Yoon et al., 2011)

1.2kb deletion that removes mir-279.

(Cayirlioglu et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception | adult stage

(Zhang et al., 2023)

abnormal behavior

(Zhang et al., 2023)

abnormal locomotor behavior | adult stage

(Sun et al., 2015)

abnormal locomotor rhythm

(Luo and Sehgal, 2012)

abnormal locomotor rhythm | adult stage | recessive | conditional

(Sun et al., 2015)

abnormal neuroanatomy | adult stage | somatic clone

(Sun et al., 2015)

abnormal neurophysiology | recessive

(Zhang et al., 2023)

decreased cell number | P-stage

(Zhang et al., 2023)

decreased cell number | P-stage (with Df(3R)ex15C)

(Zhang et al., 2023)

decreased cell number | P-stage (with mir-279^ex36)

(Zhang et al., 2023)

lethal (with Df(3R)Exel6212)

(Chen et al., 2014)

lethal | recessive

(Chen et al., 2014)

some die during embryonic stage (with Df(3R)Exel6212)

(Chen et al., 2014)

some die during embryonic stage | recessive

(Chen et al., 2014)

viable

(Sun et al., 2015)

Phenotype Manifest In

adult olfactory receptor neuron Gr21a/63a | ectopic | somatic clone

(Sun et al., 2015)

Johnston organ | P-stage

(Zhang et al., 2023)

Johnston organ | P-stage (with Df(3R)ex15C)

(Zhang et al., 2023)

Johnston organ | P-stage (with mir-279^ex36)

(Zhang et al., 2023)

maxillary palp | somatic clone

(Sun et al., 2015)

scolopale cell | P-stage

(Zhang et al., 2023)

scolopale cell | P-stage | decreased number (with Df(3R)ex15C)

(Zhang et al., 2023)

scolopale cell | P-stage | decreased number (with mir-279^ex36)

(Zhang et al., 2023)

Detailed Description

Statement

Reference

Approximately 67% of homozygous adult escapers have very weak or no locomotor activity rhythms under constant darkness conditions.

(Luo and Sehgal, 2012)

mir-279^Δ1.2 mutant egg chamber clones exhibit extra cells in between the nurse cells, indicative of an increase in JAK/STAT signalling.

Approximately 50% of egg chambers from induced mir-279^Δ1.2 clones exhibit ectopic cells or clusters of cells. The number of border cells within the main cluster remains normal, indicating the abnormal invasion of follicle cells.

mir-279^Δ1.2 mutant egg chambers exhibit frequent border-cell migration defects.

(Yoon et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mir-279^ex117 has abnormal locomotor behavior | adult stage phenotype, suppressible by mir-996^1x

(Sun et al., 2015)

mir-279^ex117 has abnormal locomotor behavior | adult stage phenotype, suppressible by mir-996^2x

(Sun et al., 2015)

mir-279^ex117 has abnormal locomotor rhythm phenotype, suppressible by upd1^NIG.5993R/Scer\GAL4^tim.UAS

(Luo and Sehgal, 2012)

Phenotype Manifest In

Other

Statement

Reference

Socs36E[+]/Socs36E¹⁷⁸, mir-279^ex117 has border follicle cell phenotype

(Monahan and Starz-Gaiano, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Egg chambers of Socs36E¹⁷⁸/+, mir-279^Δ1.2/+ double heterozygous females contain additional invasive cells that are not associated with the border cell cluster compared to either single heterozygote.

(Monahan and Starz-Gaiano, 2013)

The locomotor rhythm defects seen in mir-279^ex117-1 flies under constant darkness conditions are suppressed by expression of upd1^NIG.5993R under the control of Scer\GAL4^tim.Scer\UAS.

(Luo and Sehgal, 2012)

A Stat92E^EP3391 heterozygous background suppresses the ectopic invasive cell phenotype and the border-cell migration defects found in mir-279^Δ1.2 mutant clones.

(Yoon et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

mir-279^ex117 is rescued by mir-279^+t16

(Sun et al., 2015)

mir-279^ex117 is rescued by mir-279^1x

(Sun et al., 2015)

mir-279^ex117 is rescued by mir-279^2x

(Sun et al., 2015)

Comments

mir-279^+t3 rescues the locomotor rhythm defects of mir-279^ex117-1 adult escapers.

(Luo and Sehgal, 2012)

The presence of ectopic cells or clusters of cells in the egg chambers of mir-279^Δ1.2 mutant clones is ameliorated by the presence of mir-279^+t3.

(Yoon et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

ex117

(Duan et al., 2018, Kavaler et al., 2018)

ex117-1

(Luo and Sehgal, 2012)

miR-279^Δ1.2

(Monahan and Starz-Gaiano, 2016)

mir-279^1.2

(Monahan and Starz-Gaiano, 2013)

mir-279^ex117-1

mir-279^ex117

(Sun et al., 2015)

mir-279^Δ1.2

(Monahan and Starz-Gaiano, 2013, Yoon et al., 2011, Cayirlioglu et al., 2008)

Name Synonyms

Secondary FlyBase IDs

FBal0285333
FBal0277295

References (10)

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