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General Information
Symbol
Dmel\Socs36E178
Species
D. melanogaster
Name
FlyBase ID
FBal0285736
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate boundaries of a ~500 bp deletion resulting from the imprecise excision of P{EPgy2}Socs36EEY06665. The boundary within the first coding exon is from sequence data. The boundary in the intron is estimated. The predicted protein product has 175 aa of Socs36E followed by 3 novel amino acids before termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion that removes approximately 500bp from exon 2 and intron 2-3 of Socs36E. This introduces a frame-shift and generates an in-frame TAA stop codon which produces a truncated protein of 178 amino acid residues.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Abnormally invasive cells trail behind the main border cell cluster and are detached from it in 63% of mutant stage 10 egg chambers.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Egg chambers of Socs36E178/+, apt167/+ double heterozygous females contain additional invasive cells that are not associated with the border cell cluster: 55% of the double heterozygous egg chambers contain more than one additional invasive cell compared to 10% and 15% respectively for each single heterozygote.

In 44% of Socs36E178 aptKG05830/Socs36EEY06665 apt167 stage 10 egg chambers the border cells are tethered to the anterior end of the egg chamber by non-cluster associated invasive cells. This inability to detach from neighbouring follicle cells results in a migration delay in 31% of the stage 10 double mutant egg chambers.

Egg chambers of Socs36E178/+, mir-279Δ1.2/+ and of Socs36E178/+, mir-279Δ1.9/+ double heterozygous females contain additional invasive cells that are not associated with the border cell cluster compared to either single heterozygote.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)