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General Information
Symbol
Dmel\aptKG05830
Species
D. melanogaster
Name
FlyBase ID
FBal0223457
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    P{SUPor-P}aptKG05830
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In 75% of homozygous aptKG05830 mutant stage 10 egg chambers, 1-7 additional invasive "stretched border cells" are seen, often dramatically stretched out and trailing behind the main cluster. In about 32% of egg chambers, the cells fail to complete their migration to the oocyte.

    In ~80% of homozygous aptKG05830/apt167 mutant stage 10 egg chambers, 1-7 additional invasive "stretched border cells" are seen, often dramatically stretched out and trailing behind the main cluster.

    In ~80% of homozygous aptKG05830/apt41 mutant stage 10 egg chambers, 1-7 additional invasive "stretched border cells" are seen, often dramatically stretched out and trailing behind the main cluster.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    Statement
    Reference
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    In 44% of Socs36E178 aptKG05830/Socs36EEY06665 apt167 stage 10 egg chambers the border cells are tethered to the anterior end of the egg chamber by non-cluster associated invasive cells. This inability to detach from neighbouring follicle cells results in a migration delay in 31% of the stage 10 double mutant egg chambers.

    One copy of Stat92E06346 partially suppresses the invasive border cell phenotype seen in aptKG05830/apt167 mutant stage 10 egg chambers. A reduction is seen in both the frequency of affected egg chambers and the number of cells. On average 26% of egg chambers contain "stretched border cells" compared to ~80% in aptKG05830/apt167 alone. The border cell cluster also detaches much more easily from the anterior end of the egg chamber.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)