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General Information
Symbol
Dmel\Socs36EEY06665
Species
D. melanogaster
Name
FlyBase ID
FBal0159743
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the coding sequence, 516bp downstream of the ATG start codon.

Insertion in the second exon.

Insertion components
P{EPgy2}Socs36EEY06665
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The testes of mutant males show a significant loss of germline stem cells (GSCs), with an average of only 3.4 GSCs per testis (compared to 8.3 GSCs per testis in wild type).

Comparable numbers of marked wild-type and homozygous GSC clones are detected in males 5 and 11 days after clone induction. In all cases spermatogenesis is normal in males containing homozygous GSC clones (normal cysts with 16 differentiating spermatocytes are seen).

The somatic cyst progenitor cells (CPCs) directly contact the hub in the mutant testes, forming a tight circle around it (in wild-type testes the CPCs only make limited contacts to the hub cells through their cytoplasm extensions).

6 days after clone induction, 100% of testes carry one or more marked homozygous CPC clones, with an average of 3.7 marked homozygous CPCs per testis (compared to 92% of testes carrying one or more marked wild-type CPC clones, with an average of 1.1 marked wild-type CPCs per testis).

Homozygotes have normal eyes and normal photoreceptor organisation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

In 44% of Socs36E178 aptKG05830/Socs36EEY06665 apt167 stage 10 egg chambers the border cells are tethered to the anterior end of the egg chamber by non-cluster associated invasive cells. This inability to detach from neighbouring follicle cells results in a migration delay in 31% of the stage 10 double mutant egg chambers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4C587 rescues the mutant cyst progenitor cell phenotype seen in the testes of Socs36EEY06665 males.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)