FB2026_02 , released June 18, 2026
Allele: Dmel\Gr22eLL05566
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General Information
Symbol
Dmel\Gr22eLL05566
Species
D. melanogaster
Name
FlyBase ID
FBal0346699
Feature type
allele
Associated gene
Dmel\Gr22e
Associated Insertion(s)
PBac{SAstopDsRed}Gr22eLL05566
Carried in Construct
Also Known As
Gr22e1
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{SAstopDsRed}Gr22eLL05566
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{SAstopDsRed}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Gr22eLL05566 mutant flies do not show significant changes in the expected avoidance response to food laced with acetic acid (5%), as compared to controls.

        (Rimal et al., 2019)

        Gr22eLL05566 mutants show significantly reduced S-b sensilla responsiveness to the bitter chemicals LOB, BER, DEN, STR and SOA, but not to CAF or UMB, as compared to controls; S-a sensilla show decreased responsiveness to DEN and STR, but not to LOB, BER, CAF, SOA or UMB, as compared to controls; and I-a and I-b sensilla show no changes in responsiveness to any of the chemicals, as compared to controls. This correlates with decreased food avoidance to LOB, BER and DEN in two-way choice assays, as compared to controls.

        The expression of Gr22eUAS.cSa under the control of Scer\GAL4Gr33a-GAL4 in Gr22eLL05566 mutants rescues their decreased S-b sensilla responsiveness to LOB, BER, DEN and STR, and even induces hyper-responsiveness to all four chemicals in both S-a and S-b sensilla, ectopic responsiveness to all four chemicals in I-b sensilla, and ectopic responsiveness only to STR in I-a sensilla.

        (Sung et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Gr22eLL05566 has abnormal chemosensory behavior | adult stage phenotype, enhanceable by Gr59c1

        (Sung et al., 2017)
        Suppressed by
        Enhancer of
        Statement
        Reference

        Gr22eLL05566 is an enhancer of abnormal chemosensory behavior | adult stage phenotype of Gr59c1

        (Sung et al., 2017)
        NOT Enhancer of
        Statement
        Reference

        Gr22eLL05566 is a non-enhancer of abnormal taste perception | adult stage phenotype of Gr59c1

        (Sung et al., 2017)

        Gr22eLL05566 is a non-enhancer of abnormal neurophysiology | adult stage phenotype of Gr59c1

        (Sung et al., 2017)
        NOT Suppressor of
        Statement
        Reference

        Gr22eLL05566 is a non-suppressor of abnormal taste perception | adult stage phenotype of Gr59c1

        (Sung et al., 2017)

        Gr22eLL05566 is a non-suppressor of abnormal neurophysiology | adult stage phenotype of Gr59c1

        (Sung et al., 2017)
        Other
        Phenotype Manifest In
        Suppressed by
        NOT Enhancer of
        Statement
        Reference

        Gr22eLL05566 is a non-enhancer of intermediate labellar taste bristle phenotype of Gr59c1

        (Sung et al., 2017)
        NOT Suppressor of
        Statement
        Reference

        Gr22eLL05566 is a non-suppressor of intermediate labellar taste bristle phenotype of Gr59c1

        (Sung et al., 2017)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The expression of Gr59cUAS.cUa under the control of Scer\GAL4Gr33a-GAL4 in Gr22eLL05566 mutants rescues their decreased S-b sensilla responsiveness to the bitter chemicals LOB, BER, DEN and STR, and even induces hyper-responsiveness to LOB, BER, DEN in both S-a and S-b sensilla, and ectopic responsiveness to LOB, BER and DEN in I-b sensilla, but does not have an effect on responsiveness in I-a sensilla.

        The decreased responsiveness of S-a sensilla to LOB and DEN and the decreased responsiveness of S-b sensilla to LOB and DEN observed in Gr22eLL05566 mutants are partially suppressed by Gr59c1; the decreased responsiveness of S-b sensilla to BER is not affected by Gr59c1. The lack of responsiveness of I-a sensilla observed in Gr59c1 mutants is not suppressed by Gr22eLL05566.

        The decreased food avoidance to the bitter chemicals LOB, BER and DEN observed in Gr22eLL05566 mutants is enhanced by Gr59c1.

        (Sung et al., 2017)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Gr22e1
        (Aryal and Lee, 2022, Rimal and Lee, 2019, Rimal et al., 2019, Sang et al., 2019, Poudel et al., 2017, Sung et al., 2017)
        Gr22eLL05566
        Name Synonyms
        Secondary FlyBase IDs
          References (6)