FlyBase Allele Report: Dmel\Gr59c[UAS.cUa]

General Information

Symbol

Dmel\Gr59c^UAS.cUa

Species

D. melanogaster

Name

UAS construct a of Unknown

FlyBase ID

FBal0346765

Feature type

allele

Associated gene

Dmel\Gr59c

Associated Insertion(s)

Carried in Construct

P{UAS-Gr59c.U}

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Gr59c.U}

Cytology

Description

UAS regulatory sequences drive expression of Gr59c.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Gr59c

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage, with Gr59c¹

(Sung et al., 2017)

abnormal taste perception | adult stage, with Gr59c¹

(Sung et al., 2017)

Phenotype Manifest In

intermediate labellar taste bristle, with Gr59c¹

(Sung et al., 2017)

short labellar taste bristle, with Gr59c¹

(Sung et al., 2017)

Detailed Description

Statement

Reference

The expression of Gr59c^UAS.cUa under the control of Scer\GAL4^Gr64f.9.7 is not sufficient to make L-type sensilla responsive to the bitter chemicals LOB, BER and DEN.

The expression of Gr59c^UAS.cUa under the control of Scer\GAL4^Gr33a-GAL4 in Gr59c¹ mutants rescues their decreased I-a sensilla responsiveness to the bitter chemicals LOB, BER and DEN, and even induces hyper-responsiveness to LOB, BER and DEN in I-b, S-a and S-b sensilla.

(Sung et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal taste perception | adult stage phenotype, non-suppressible by Df(3L)ΔGr64af

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Df(3L)ΔGr64af

(Sung et al., 2017)

Suppressor of

Statement

Reference

Gr59c^UAS.cUa/Scer\GAL4^Gr33a-GAL4 is a suppressor of abnormal taste perception | adult stage phenotype of Gr22e^LL05566

(Sung et al., 2017)

Gr59c^UAS.cUa/Scer\GAL4^Gr33a-GAL4 is a suppressor of abnormal neurophysiology | adult stage phenotype of Gr22e^LL05566

(Sung et al., 2017)

Other

Statement

Reference

Gr22e^LL05566, Gr59c^UAS.cUa, Scer\GAL4^Gr33a-GAL4 has abnormal neurophysiology | adult stage phenotype

(Sung et al., 2017)

Gr22e^LL05566, Gr59c^UAS.cUa, Scer\GAL4^Gr33a-GAL4 has abnormal taste perception | adult stage phenotype

(Sung et al., 2017)

Df(3L)ΔGr64af, Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal neurophysiology | adult stage phenotype

(Sung et al., 2017)

Df(3L)ΔGr64af, Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal taste perception | adult stage phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr33a^UAS.cMa, Gr39a^UAS.a.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Gr89a^UAS.cSa, Scer\GAL4^Gr64f.9.7 has abnormal neurophysiology | adult stage phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr33a^UAS.cMa, Gr39a^UAS.a.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Gr89a^UAS.cSa, Scer\GAL4^Gr64f.9.7 has abnormal taste perception | adult stage phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal neurophysiology | adult stage phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has abnormal taste perception | adult stage phenotype

(Sung et al., 2017)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has large labellar taste bristle phenotype, non-suppressible by Df(3L)ΔGr64af

(Sung et al., 2017)

Suppressor of

Statement

Reference

Gr59c^UAS.cUa/Scer\GAL4^Gr33a-GAL4 is a suppressor of short labellar taste bristle phenotype of Gr22e^LL05566

(Sung et al., 2017)

Other

Statement

Reference

Df(3L)ΔGr64af, Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has large labellar taste bristle phenotype

(Sung et al., 2017)

Gr22e^LL05566, Gr59c^UAS.cUa, Scer\GAL4^Gr33a-GAL4 has intermediate labellar taste bristle phenotype

(Sung et al., 2017)

Gr22e^LL05566, Gr59c^UAS.cUa, Scer\GAL4^Gr33a-GAL4 has short labellar taste bristle phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr33a^UAS.cMa, Gr39a^UAS.a.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Gr89a^UAS.cSa, Scer\GAL4^Gr64f.9.7 has large labellar taste bristle phenotype

(Sung et al., 2017)

Gr32a^UAS.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC, Scer\GAL4^Gr64f.9.7 has large labellar taste bristle phenotype

(Sung et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The sextuple co-expression of Gr32a^UAS.cSa, Gr33a^UAS.cMa, Gr39a^UAS.a.cSa, Gr59c^UAS.cUa, Gr66a^UAS.Tag:MYC and Gr89a^UAS.cSa under the control of Scer\GAL4^Gr64f.9.7 makes L-type sensilla responsive to the bitter chemicals LOB, BER, and DEN, but not to the bitter chemicals CAF, STR, SOA or UMB. Control L-type sensilla, however, are only responsive to sucrose; this sextuple co-expression has no effect on the normal response to sucrose.

Only quintuple co-expression combinations that include Gr32a^UAS.cSa, Gr59c^UAS.cUa and Gr66a^UAS.Tag:MYC induce responsiveness of L-type sensilla to LOB, BER, and DEN. In agreement, the triple co-expression of Gr32a^UAS.cSa, Gr59c^UAS.cUa and Gr66a^UAS.Tag:MYC is sufficient to induce responsiveness to LOB, BER, and DEN, but not to CAF, STR, SOA, or UMP, whereas all double combinations of these three do not. All mentioned quintuple, triple and double co-expression have no effect on the normal response to sucrose.

L-type sensilla co-expressing Gr32a^UAS.cSa, Gr59c^UAS.cUa and Gr66a^UAS.Tag:MYC under the control of Scer\GAL4^Gr64f.9.7 show the expected responsiveness to sucrose and ectopic responsiveness to the bitter chemicals LOB, BER and DEN. Df(3L)ΔGr64af abolishes the expected responsiveness to sucrose, but not the bitter chemicals.

The expression of Gr59c^UAS.cUa under the control of Scer\GAL4^Gr33a-GAL4 in Gr22e^LL05566 mutants rescues their decreased S-b sensilla responsiveness to LOB, BER, DEN and STR, and even induces hyper-responsiveness to LOB, BER, DEN in both S-a and S-b sensilla, and ectopic responsiveness to LOB, BER and DEN in I-b sensilla, but does not have an effect on responsiveness in I-a sensilla.

(Sung et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Gr59c^UAS.cUa/Scer\GAL4^Gr33a-GAL4 rescues Gr59c¹

(Sung et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Gr59c^UAS.cUa

Name Synonyms

UAS construct a of Unknown

Secondary FlyBase IDs

References (2)

Report Sections

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