FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gr33aUAS.cMa
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General Information
Symbol
Dmel\Gr33aUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Moon
FlyBase ID
FBal0243784
Feature type
allele
Associated gene
Dmel\Gr33a
Associated Insertion(s)
Carried in Construct
P{UAS-Gr33a.M}
Also Known As
UAS-Gr33a
Key Links
Transgenic product class
wild_type
(Moon et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Moon et al., 2009)
Mutagen
in vitro construct
(Moon et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Gr33a.M}
Cytology
Description

UASt regulatory sequences drive expression of the full coding region of Gr33a.

(Moon et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gr33a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The sextuple co-expression of Gr32aUAS.cSa, Gr33aUAS.cMa, Gr39aUAS.a.cSa, Gr59cUAS.cUa, Gr66aUAS.Tag:MYC and Gr89aUAS.cSa under the control of Scer\GAL4Gr64f.9.7 makes L-type sensilla responsive to the bitter chemicals LOB, BER, and DEN, but not to the bitter chemicals CAF, STR, SOA or UMB. Control L-type sensilla, however, are only responsive to sucrose; this sextuple co-expression has no effect on the normal response to sucrose.

      Only quintuple co-expression combinations that include Gr32aUAS.cSa, Gr59cUAS.cUa and Gr66aUAS.Tag:MYC induce responsiveness of L-type sensilla to LOB, BER, and DEN. In agreement, the triple co-expression of Gr32aUAS.cSa, Gr59cUAS.cUa and Gr66aUAS.Tag:MYC is sufficient to induce responsiveness to LOB, BER, and DEN, but not to CAF, STR, SOA, or UMP, whereas all double combinations of these three do not. All mentioned quintuple, triple and double co-expression have no effect on the normal response to sucrose.

      (Sung et al., 2017)

      As in control flies, co-expression of Gr32aScer\UAS.cMa, Gr33aScer\UAS.cMa, Gr47aScer\UAS.cLa and Gr66aScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Gr5a.PUn does not elicit action potentials in sugar-responsive gustatory receptor neurons upon application of strychnine.

      (Lee et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Gr33a-GAL4/Gr33aUAS.cMa rescues Gr33a1/Gr33aGAL4

      (Hu et al., 2015)

      Scer\GAL4Gr33a-GAL4/Gr33aUAS.cMa rescues Gr33a1/Gr33aGAL4

      (Moon et al., 2009)

      Scer\GAL4Gr33a-GAL4/Gr33aUAS.cMa rescues Gr33a1/Gr33aGAL4

      (Moon et al., 2009)
      Partially rescues

      Scer\GAL4Gr33a-GAL4/Gr33aUAS.cMa partially rescues Gr33a1/Gr33a[+]

      (Poudel et al., 2015)
      Comments

      Expression of Gr33aScer\UAS.cMa under the control of Scer\GAL4Gr33a-GAL4 rescues the male courtship defect of Gr33a1/Gr33aGAL4 mutants.

      (Hu et al., 2015)

      Expression of Gr33aScer\UAS.cMa under the control of Scer\GAL4Gr33a-GAL4 in the Gr33a1 heterozygote adults significantly recovers the perturbed avoidance of umbelliferone in a two-way choice feeding assay as well as the site selection for oviposition assay and restores the reduction in frequency of action potentials invoked in the S6 sensilla upon umbelliferone exposure.

      (Poudel et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gr33aScer\UAS.cMa
      Gr33aUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Moon
      Secondary FlyBase IDs
        References (9)