FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gr22eUAS.cSa
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General Information
Symbol
Dmel\Gr22eUAS.cSa
Species
D. melanogaster
Name
UAS construct a of Sung
FlyBase ID
FBal0346756
Feature type
allele
Associated gene
Dmel\Gr22e
Associated Insertion(s)
Carried in Construct
P{UAS-Gr22e.S}
Key Links
Transgenic product class
cDNA
(Sung et al., 2017)
wild_type
(Sung et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Sung et al., 2017)
wild_type
(Sung et al., 2017)
Mutagen
in vitro construct
(Sung et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Gr22e.S}
Cytology
Description

UASt regulatory sequences drive expression of a Gr22e cDNA.

(Sung et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gr22e
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Gr22eUAS.cSa under the control of Scer\GAL4Gr33a-GAL4 in Gr22eLL05566 mutants rescues their decreased S-b sensilla responsiveness to the bitter chemicals LOB, BER, DEN and STR, and even induces hyper-responsiveness to all four chemicals in both S-a and S-b sensilla, ectopic responsiveness to all four chemicals in I-b sensilla, and ectopic responsiveness only to STR in I-a sensilla.

      (Sung et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The triple co-expression of Gr32aUAS.cSa, Gr66aUAS.Tag:MYC and Gr22eUAS.cSa under the control of Scer\GAL4Gr64f.9.7 makes L-type sensilla responsive to the bitter chemicals LOB, BER, DEN, STR and UMB, but not to CAF or SOA, while not affecting the normal response to sucrose. Df(3L)ΔGr64af abolishes the responsiveness to sucrose, reduces the ectopic responsiveness to STR, but has no effect on the ectopic responsiveness to LOB, BER and DEN.

      The expression of Gr22eUAS.cSa under the control of Scer\GAL4Gr33a-GAL4 in Gr59c1 mutants rescues their decreased I-a sensilla responsiveness to LOB, BER and DEN, and even induces hyper-responsiveness to LOB and STR in both I-a and I-b sensilla, ectopic responsiveness to LOB, BER, DEN and STR in I-b sensilla, and hyper-responsiveness in S-a and S-b sensilla to all four chemicals.

      (Sung et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gr22eUAS.cSa
      Name Synonyms
      UAS construct a of Sung
      Secondary FlyBase IDs
        References (1)