FlyBase Allele Report: Dmel\Gr59c[1]

General Information

Symbol

Dmel\Gr59c¹

Species

D. melanogaster

Name

FlyBase ID

FBal0346764

Feature type

allele

Associated gene

Dmel\Gr59c

Associated Insertion(s)

TI{TI}Gr59c¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

gene targeting by homologous recombination

Nature of the Allele

Allele class

Mutagen

gene targeting by homologous recombination

(Sung et al., 2017)

Progenitor genotype

Associated Insertion(s)

TI{TI}Gr59c¹

Cytology

Description

Most of the Gr59c coding region has been deleted. Sequence encoding a w^+* marker has been inserted in place of the deleted sequence.

(Sung et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:23,102,690..23,103,733 [-]

Comment:

Most of the Gr59c coding region has been deleted by homologous recombination. Sequence encoding the Scer\GAL4 driver, plus a w^+mW.hs marker, has been inserted in place of the deleted sequence. Position of deletion endpoints on reference sequence determined from reported primer sequences.

(Sung et al., 2017)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | adult stage

(Sung et al., 2017)

abnormal neurophysiology | adult stage

(Sung et al., 2017)

abnormal neurophysiology | adult stage, with Gr59c^UAS.cUa

(Sung et al., 2017)

abnormal taste perception | adult stage

(Sung et al., 2017)

abnormal taste perception | adult stage, with Gr59c^UAS.cUa

(Sung et al., 2017)

Phenotype Manifest In

intermediate labellar taste bristle

(Sung et al., 2017)

intermediate labellar taste bristle, with Gr59c^UAS.cUa

(Sung et al., 2017)

short labellar taste bristle

(Sung et al., 2017)

short labellar taste bristle, with Gr59c^UAS.cUa

(Sung et al., 2017)

Detailed Description

Statement

Reference

Gr59c¹ mutant I-a sensilla do not show the expected responsiveness to the bitter chemicals LOB, BER or DEN observed in controls, show ectopic responsiveness to CAF and UMB, and show the same lack of responsiveness to STR and SOA as controls; S-a sensilla show increased responsiveness to STR, but no changes in responsiveness to the other chemicals, as compared to controls; S-b sensilla show increased responsiveness to CAF, decreased responsiveness to BER, but no changes in responsiveness to other chemicals, as compared to controls; and I-b sensilla show no changes in responsiveness to any of the chemicals, as compared to controls. This correlates with decreased food avoidance to LOB, BER and DEN in two-way choice assays, as compared to controls.

The expression of Gr59c^UAS.cUa under the control of Scer\GAL4^Gr33a-GAL4 in Gr59c¹ mutants rescues their decreased I-a sensilla responsiveness of to the bitter chemicals LOB, BER and DEN, and even induces hyper-responsiveness to LOB, BER and DEN in I-b, S-a and S-b sensilla.

(Sung et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gr59c¹ has abnormal chemosensory behavior | adult stage phenotype, enhanceable by Gr22e^LL05566

(Sung et al., 2017)

NOT Enhanced by

Statement

Reference

Gr59c¹ has abnormal taste perception | adult stage phenotype, non-enhanceable by Gr22e^LL05566

(Sung et al., 2017)

Gr59c¹ has abnormal neurophysiology | adult stage phenotype, non-enhanceable by Gr22e^LL05566

(Sung et al., 2017)

Suppressed by

Statement

Reference

Gr59c¹ has abnormal taste perception | adult stage phenotype, suppressible by Gr22e^UAS.cSa/Scer\GAL4^Gr33a-GAL4

(Sung et al., 2017)

Gr59c¹ has abnormal neurophysiology | adult stage phenotype, suppressible by Gr22e^UAS.cSa/Scer\GAL4^Gr33a-GAL4

(Sung et al., 2017)

NOT suppressed by

Statement

Reference

Gr59c¹ has abnormal taste perception | adult stage phenotype, non-suppressible by Gr22e^LL05566

(Sung et al., 2017)

Gr59c¹ has abnormal neurophysiology | adult stage phenotype, non-suppressible by Gr22e^LL05566

(Sung et al., 2017)

Enhancer of

Statement

Reference

Gr59c¹ is an enhancer of abnormal chemosensory behavior | adult stage phenotype of Gr22e^LL05566

(Sung et al., 2017)

Suppressor of

Statement

Reference

Gr59c¹ is a suppressor | partially of abnormal taste perception | adult stage phenotype of Gr22e^LL05566

(Sung et al., 2017)

Gr59c¹ is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Gr22e^LL05566

(Sung et al., 2017)

Other

Statement

Reference

Gr22e^UAS.cSa, Gr59c¹, Scer\GAL4^Gr33a-GAL4 has abnormal neurophysiology | adult stage phenotype

(Sung et al., 2017)

Gr22e^UAS.cSa, Gr59c¹, Scer\GAL4^Gr33a-GAL4 has abnormal taste perception | adult stage phenotype

(Sung et al., 2017)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Gr59c¹ has intermediate labellar taste bristle phenotype, non-enhanceable by Gr22e^LL05566

(Sung et al., 2017)

Suppressed by

Statement

Reference

Gr59c¹ has intermediate labellar taste bristle phenotype, suppressible by Gr22e^UAS.cSa/Scer\GAL4^Gr33a-GAL4

(Sung et al., 2017)

NOT suppressed by

Statement

Reference

Gr59c¹ has intermediate labellar taste bristle phenotype, non-suppressible by Gr22e^LL05566

(Sung et al., 2017)

Suppressor of

Statement

Reference

Gr59c¹ is a suppressor | partially of short labellar taste bristle phenotype of Gr22e^LL05566

(Sung et al., 2017)

Other

Statement

Reference

Gr22e^UAS.cSa, Gr59c¹, Scer\GAL4^Gr33a-GAL4 has intermediate labellar taste bristle phenotype

(Sung et al., 2017)

Gr22e^UAS.cSa, Gr59c¹, Scer\GAL4^Gr33a-GAL4 has short labellar taste bristle phenotype

(Sung et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Gr22e^UAS.cSa under the control of Scer\GAL4^Gr33a-GAL4 in Gr59c¹ mutants rescues their decreased I-a sensilla responsiveness to LOB, BER and DEN, and even induces hyper-responsiveness to LOB and STR in both I-a and I-b sensilla, ectopic responsiveness to LOB, BER, DEN and STR in I-b sensilla, and hyper-responsiveness in S-a and S-b sensilla to all four chemicals.

The decreased responsiveness of S-a sensilla to LOB and DEN and the decreased responsiveness of S-b sensilla to LOB and DEN observed in Gr22e^LL05566 mutants are partially suppressed by Gr59c¹; the decreased responsiveness of S-b sensilla to BER is not affected by Gr59c¹. The lack of responsiveness of I-a sensilla observed in Gr59c¹ mutants is not suppressed by Gr22e^LL05566.

The decreased food avoidance to the bitter chemicals LOB, BER and DEN observed in Gr59c¹ mutants is enhanced by Gr22e^LL05566.

(Sung et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Gr59c¹ is rescued by Gr59c^UAS.cUa/Scer\GAL4^Gr33a-GAL4

(Sung et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Gr59c¹

(Dhakal et al., 2021, Sang et al., 2019, Sung et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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