FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shepRRM.UAS.E
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General Information
Symbol
Dmel\shepRRM.UAS.E
Species
D. melanogaster
Name
FlyBase ID
FBal0346885
Feature type
allele
Associated gene
Dmel\shep
Associated Insertion(s)
Carried in Construct
P{UAS-shep.E.RRM}
Key Links
Transgenic product class
missense_variant
(Chen et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chen et al., 2019)
Mutagen
in vitro construct
(Chen et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-shep.E.RRM}
Cytology
Description

UASt regulatory sequences drive expression of the shep E isoform. The coding sequence has been mutated to carry point mutations in both of the conserved RNA-binding domains (amino acid substitutions Y64A, F66A, F69A in the RNP1 domain of RRM1 and V162A, F164A, R166A in the RNP1 domain of RRM2).

(Chen et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
shep
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      shepRRM.UAS.E/Scer\GAL4Ser.PGF is a non-suppressor of wing margin | adult stage phenotype of ct6, mod(mdg4)ul, shepd05714

      (Chen et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      shepRRM.UAS.E/Scer\GAL4Ser.PGF fails to rescue shepBG00836

      (Chen et al., 2019)
      Comments

      Expressing shepUAS.E under the control of Scer\GAL4Ser.PGF fails to rescue the reduced soma size and axonal phenotype of shepBG00836/shepBG00836 Burs-positive CCAP neurons in pharate adults.

      (Chen et al., 2019)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      shepRRM.UAS.E
      Name Synonyms
      Secondary FlyBase IDs
        References (1)