FlyBase Allele Report: Dmel\S-Lap5[Δ14]

General Information

Symbol

Dmel\S-Lap5^Δ14

Species

D. melanogaster

Name

FlyBase ID

FBal0346895

Feature type

allele

Associated gene

Dmel\S-Lap5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Laurinyecz et al., 2019)

Progenitor genotype

Cytology

Description

14bp deletion within S-Lap5.

(Laurinyecz et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:13,597,749..13,597,762 [+]

Comment:

14bp deletion within S-Lap5 leads to a frameshift.

(Sinka, 2019.6.11)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile (with Df(2R)CX1)

(Laurinyecz et al., 2019)

male sterile | recessive

(Laurinyecz et al., 2019)

Phenotype Manifest In

sperm individualization complex

(Laurinyecz et al., 2019)

Detailed Description

Statement

Reference

Spermatogenesis in S-Lap1^Δ7 homozygotes shows normal cell divisions, normal nebenkern number and formation, normal length of elongated cysts, and normal establishment of individualization complexes around the needle shaped nuclei; however, there are few individualization complexes, which migrate less frequently and more asynchronously, as compared to controls.

(Laurinyecz et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

S-Lap5^Δ14 has male sterile | recessive phenotype, suppressible by loopin-1^+tLa

(Laurinyecz et al., 2019)

NOT suppressed by

Statement

Reference

S-Lap5^Δ14 has male sterile | recessive phenotype, non-suppressible by S-Lap1^int.Tag:HA

(Laurinyecz et al., 2019)

Enhancer of

Statement

Reference

S-Lap5[+]/S-Lap5^Δ14 is an enhancer of male semi-sterile | dominant phenotype of S-Lap1^Δ7

(Laurinyecz et al., 2019)

Other

Statement

Reference

S-Lap1^Δ7, S-Lap5[+]/S-Lap5^Δ14 has male semi-sterile | dominant phenotype

(Laurinyecz et al., 2019)

S-Lap3^MB01319, S-Lap5[+]/S-Lap5^Δ14 has male semi-sterile | dominant phenotype

(Laurinyecz et al., 2019)

S-Lap5^Δ14, loopin-1[+]/loopin-1^MI06848 has semi-sterile | dominant phenotype

(Laurinyecz et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

S-Lap5^Δ14/+, S-Lap4^MB11296/+ males are fertile; S-Lap5^Δ14/+, S-Lap4^MB11296/+ yield fewer offspring than controls. S-Lap2^MI14597/+, S-Lap5^Δ14/+ males yield fewer offspring than S-Lap2^MI14597/+ controls, but not S-Lap5^Δ14/+ controls. S-Lap5^Δ14/+, S-Lap1^Δ7/+ males are almost sterile.

(Laurinyecz et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

S-Lap5^Delta14

(Sinka, 2019.6.11)

S-Lap5^Δ14

(Laurinyecz et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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