FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\Piezo1TriM.UAS
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General Information
Symbol
Mmus\Piezo1TriM.UAS
Species
M. musculus
Name
FlyBase ID
FBal0348142
Feature type
allele
Associated gene
Mmus\Piezo1
Associated Insertion(s)
Carried in Construct
P{UAS-mPiezo1.TriM}
Also Known As
UAS-mPiezo1-TriM
Transgenic product class
gain_of_function_variant
(Song et al., 2019)
missense_variant
(Song et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Song et al., 2019)
missense_variant
(Song et al., 2019)
Mutagen
in vitro construct
(Song et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-mPiezo1.TriM}
Cytology
Description

UAS regulatory sequences drive expression of the Mmus\Piezo1 coding sequence, mutated to carry the E2133D, D2139E and D2144E amino acid replacements. This results in a gain-of-function protein due to slow inactivation kinetics.

(Song et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmus\Piezo1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of abnormal neuroanatomy | larval stage | conditional phenotype of mei-4129D

      (Li et al., 2021)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of axon | larval stage | conditional phenotype of mei-4129D

      (Li et al., 2021)

      Scer\GAL419-12/Mmus\Piezo1TriM.UAS is a non-suppressor of larval multidendritic class III neuron | conditional phenotype of mei-4129D

      (Li et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmus\Piezo1TriM.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)