FB2026_02 , released June 18, 2026
Allele: Dmel\pnΔ
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General Information
Symbol
Dmel\pnΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0348176
Feature type
allele
Associated gene
Dmel\pn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Chen et al., 2019)
Mutagen
CRISPR/Cas9
(Chen et al., 2019)
Progenitor genotype
Cytology
Description

A stop codon has been introduced into the DDH domain of pn.

(Chen et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
X:2,181,534..2,181,559 [+]
Comment:

A 26bp region is deleted and replaced with nine bases (GATAAGCTT) that includes an in-frame stop codon.

Inserted_sequence:

GATAAGCTT

(Chen et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pnΔ third instar larvae exhibit a significant reduction in the percentage of cellular area marked for mitochondria (sqh-mitoEYFP) in the proventriculus cells from the foregut compared to controls. pnΔ adults also exhibit brownish-purple eyes and an increased sensitivity to oxidative stress (induced by feeding with paraquat) when compared to controls.

      pnΔ adults exhibit a significant reduction in the amplitude of locomotor activity rhythm (circadian rhythm) under constant darkness while they exhibit normal circadian periods with normal percentages of rhythmic flies under constant darkness; normal bimodal activity patterns and anticipation under light-dark conditions; normal cell bodies and axonal projections of PDF-expressing circadian pacemaker neurons when compared to controls.

      (Chen et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pnΔ
      (Chen et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)