FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\p53A2.3
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General Information
Symbol
Dmel\p53A2.3
Species
D. melanogaster
Name
FlyBase ID
FBal0349327
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Chakravarti et al., 2022, Robin et al., 2019)
Progenitor genotype
Cytology
Description

23bp deletion plus 7bp insertion within the unique 5' exon of the p53 A mRNA. The deletion extends into the first intron, removing both coding sequence and the first splice donor site. The deleted sequence is shared with the p53 C mRNA (which is predicted to produce a protein isoform identical to that encoded by the p53 A mRNA). The mutation thus specifically disrupts protein coding of both the A and C isoforms, while expression of isoform B is unaffected.

(Chakravarti et al., 2022)

23bp deletion that is specific for the p53 p53A ('ΔNp53') isoform; deletion spans the first exon/intron junction of the p53A transcript, deleting part of the unique p53A coding sequence and the splice donor site (deletion coordinates 3R:23053346..23053368 , release 6 genome).

(Robin et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:23,053,346..23,053,368 [-]
Comment:

23bp deletion that spans the first exon/intron junction of the p53-RA transcript, deleting part of the first unique exon that encodes p53-RA and the RNA splice donor site (deletion coordinates 3R:23053346..23053368 , release 6 genome). A 7bp insertion of TACTGCT is present.

Inserted_sequence:

TACTGCT

(Robin et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      p53A2.3 has abnormal DNA repair | oogenesis phenotype, suppressible by mei-W681

      (Chakravarti et al., 2022)
      NOT Suppressor of
      Statement
      Reference

      p53A2.3 is a non-suppressor of female sterile phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)

      p53A2.3 is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      p53A2.3 has ovariole phenotype, suppressible by mei-W681

      (Chakravarti et al., 2022)
      Suppressor of
      Statement
      Reference

      p53A2.3 is a suppressor | partially of karyosome phenotype of okrAA/okrRU

      (Chakravarti et al., 2022)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      p53A2.3
      (Chakravarti et al., 2022, Robin et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)