FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Top3βC660R.UAS.Tag:FLAG
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General Information
Symbol
Dmel\Top3βC660R.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0349517
Feature type
allele
Associated gene
Dmel\Top3β
Associated Insertion(s)
Carried in Construct
P{UAS-Top3β.C660R}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Ahmad et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ahmad et al., 2017)
Mutagen
in vitro construct
(Ahmad et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Top3β.C660R}
Cytology
Description

UAS regulates expression of Tag:FLAG-tagged Top3β with a C660R mutation, which corresponds to the human C666R mutant in human Top3β found in autism patients.

(Ahmad et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Top3β
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,285,280..6,285,280 [-]
Nucleotide change:

T6285280C

Reported nucleotide change:

TGC>CGC

Amino acid change:

C660R | Top3beta-PA; C660R | Top3beta-PB

Reported amino acid change:

C660R

Comment:

Analogous C666R mutation in human TOP3B implicated in autism spectrum disorder; mutation carried on in vitro construct.

(Ahmad et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Ahmad et al., 2017)
      TOP3B:p.Cys666Arg
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      TOP3B:p.Cys530Arg
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Top3βC660R.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)