FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MICU327
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General Information
Symbol
Dmel\MICU327
Species
D. melanogaster
Name
FlyBase ID
FBal0351714
Feature type
allele
Associated gene
Dmel\MICU3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Tufi et al., 2019)
Mutagen
CRISPR/Cas9
(Tufi et al., 2019)
Progenitor genotype
Cytology
Description

A single-base deletion ( 3R:19850278 (Release 6)) in MICU3 that leads to a frameshift and early truncation. This mutation also substantially de-stabilizes the MICU3 transcript.

(Tufi et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:19,850,278..19,850,278 [+]
Comment:

A 1bp deletion in the MICU3 coding region leads to a frameshift and early translation termination.

(Tufi et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MICU327 mutant adults have a significant reduction in climbing ability at 2 days, and at 20 days, after eclosion, compared to controls.

      (Tufi et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      MICU327/MICU327 is an enhancer of short lived phenotype of Tmbim5KO

      (Zhang et al., 2025)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MICU327
      (Zhang et al., 2025, Li et al., 2023, Tufi et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)