FB2026_02 , released June 18, 2026
Allele: Dmel\DefSK4
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General Information
Symbol
Dmel\DefSK4
Species
D. melanogaster
Name
FlyBase ID
FBal0352245
Feature type
allele
Associated gene
Dmel\Def
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Parvy et al., 2019)
Progenitor genotype
Cytology
Description

8bp deletion within the Def Pro-domain.

(Parvy et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:10,054,490..10,054,497 [-]
Comment:

8bp deletion within the Def Pro-domain. The deletion coordinates were determined from the reported junction sequences.

(Parvy et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by dlg1A40.2
      (Parvy et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      DefSK4 is an enhancer of neoplasia | larval stage phenotype of dlg1A40.2

      (Parvy et al., 2019)
      Suppressor of
      Statement
      Reference

      DefSK4 is a suppressor of increased cell death | larval stage phenotype of dlg1A40.2

      (Parvy et al., 2019)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      DefSK4 is an enhancer of wing disc phenotype of dlg1A40.2

      (Parvy et al., 2019)
      Suppressor of
      Statement
      Reference

      DefSK4 is a suppressor of wing disc phenotype of dlg1A40.2

      (Parvy et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      DefSK4 enhances the tumor phenotype while suppressing the associated apoptosis (Dcp1 staining) of dlg1A40.2 wing discs, but does not affect the cell division rate.

      (Parvy et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DefSK4
      defsk4
      (Parvy et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)