FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cindr1
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General Information
Symbol
Dmel\cindr1
Species
D. melanogaster
Name
FlyBase ID
FBal0352304
Feature type
allele
Associated gene
Dmel\cindr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Ojelade et al., 2019)
Mutagen
FLPase
(Ojelade et al., 2019)
Progenitor genotype
PBac{RB}CG15544e03116
(Ojelade et al., 2019)
PBac{WH}cindrf01073
(Ojelade et al., 2019)
Cytology
Description

FRT-mediated recombination between the progenitor insertions (PBac{WH}cindrf01073 and PBac{RB}CG15544e03116) results in deletion of cindr.

(Ojelade et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Ojelade et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cindr1/cindr1 and cindr1/Df(3R)Exel6217 30-day old adult brains have no obvious morphological defects or evidence of neurodegeneration, compared to controls; aged cindr1/Df(3R)Exel6217 adults additionally do not have ommatidial patterning defects, retinal degeneration or photoreceptor synaptic terminal defects in the lamina, compared to controls; cindr1 homozygotes do not have photoreceptor projection defects in the lamina or impairments in phototransduction, compared to controls; 10-day-old cindr1/cindr1 and cindr1/Df(3R)Exel6217 adult brains have no increase in apoptosis (TUNEL), compared to controls.

      cindr1/Df(3R)Exel6217 larvae do not have defects in bouton size or number at the neuromuscular junction (NMJ), compared to controls; there is a significant increase in the number of incompletely differentiated (ghost) boutons in cindr1/cindr1 and cindr1/Df(3R)Exel6217, but not cindr1/+ larval NMJs; cindr1/Df(3R)Exel6217 larval NMJ boutons sometimes lack a sub-synaptic reticulum and active zones, unlike controls, there is also significantly increased occurrence of elongated boutons and enlarged vesicles and significantly decreased vesicle density and presence of mitochondria, compared to controls.

      cindr1/Df(3R)Exel6217 larval NMJ miniature excitatory junction potentials (EJPs) are similar to those of controls; evoked EJPs are significantly reduced at low, but not high, external calcium concentration and paired-pulse facilitation is increased in cindr1/cindr1 and cindr1/Df(3R)Exel6217 NMJs, compared to controls; there is no reduction in evoked EJP amplitude in cindr1/+ NMJs; in cindr1/Df(3R)Exel6217 NMJs there is also increased synaptic depression, with significantly fewer vesicles released over 10 min, compared to controls.

      (Ojelade et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cindr1/+, 14-3-3ζ2.3/+ double heterozygous larvae have significantly increased numbers of incompletely differentiated (ghost) boutons and significantly reduced amplitude of evoked excitatory junction potentials in the neuromuscular junction, compared to controls.

      cindr1/+, 14-3-3ζ12BL/+ double heterozygous larvae have significantly reduced amplitude of evoked excitatory junction potentials in the neuromuscular junction, compared to controls.

      (Ojelade et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cindr1
      (Ojelade et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)