FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PLD3V232M.UAS.Tag:FLAG,Tag:HA
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General Information
Symbol
Hsap\PLD3V232M.UAS.Tag:FLAG,Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0352377
Feature type
allele
Associated gene
Hsap\PLD3
Associated Insertion(s)
Carried in Construct
P{UAS-FLAG::hPLD3::HA.V232M}
Key Links
Transgenic product class
missense_variant
(Demirev et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Demirev et al., 2019)
Mutagen
in vitro construct
(Demirev et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-FLAG::hPLD3::HA.V232M}
Cytology
Description

UAS regulatory sequences drive expression of a Hsap\PLD3 cDNA that has been mutated to carry the V232M amino acdi substitution. The coding sequence is tagged at the N-terminal end with Tag:FLAG and at the C-terminal end with Tag:HA.

(Demirev et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\PLD3
Tagged with
Tag:FLAG
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT ameliorate  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.E693G.UAS.VTR
      (Demirev et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Expression of the PLD3[V232M] variant ameliorates some aspects of the Hsap\APP[Aβ42.E693G.UAS.VTR] disease model (though less so than expression of PLD3[WT]), while other aspects are not ameliorated by PLD3[V232M] expression at all.

      (Demirev et al., 2019)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\PLD3V232M.UAS.Tag:FLAG,Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)