FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PKDcl4
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General Information
Symbol
Dmel\PKDcl4
Species
D. melanogaster
Name
FlyBase ID
FBal0353070
Feature type
allele
Associated gene
Dmel\PKD
Associated Insertion(s)
TI{TI}PKDcl4
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Maier et al., 2019)
Mutagen
cre recombinase
(Maier et al., 2019)
Progenitor genotype
TI{TI}PKD26
(Maier et al., 2019)
Associated Insertion(s)
TI{TI}PKDcl4
Cytology
Description

The loxP cassette containing a w+mW.hs marker has been excised from TI{TI}PKD26. A single loxP site remains.

(Maier et al., 2019)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PKDcl4 homozygotes do not show any apparent phenotype with respect to development, size, or the overall pattern of the external organs. Females show normal fecundity. Adults show normal resistance to oxidative stress, starvation and high sugar diet. Larvae do not exhibit significant weight changes, as compared to controls. There are no defects in border cell migration behavior during oogenesis and there are no defects in pole cell number or pole cell migration behavior during embryogenesis.

      (Maier et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PKDcl4
      (Deichsel et al., 2024, Deichsel et al., 2024, Maier et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)