FlyBase Allele Report: Hsap\MAPT[UAS.0N4R.cUa]

General Information

Symbol

Hsap\MAPT^UAS.0N4R.cUa

Species

H. sapiens

Name

FlyBase ID

FBal0353103

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{UAS-hMAPT.0N4R.U}

Also Known As

UAS-htau^0N4R, UAS-Tau^WT

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-hMAPT.0N4R.U}

Cytology

Description

UAS regulatory sequences drive expression of the wild-type 0N4R isoform of Hsap\MAPT.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Yu et al., 2024, Vourkou et al., 2023, Nangia et al., 2021, Keramidis et al., 2020, Buhl et al., 2019, Scarpelli et al., 2019, Sealey et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of tauopathy

is ameliorated by Tbh^{MI04010-TG4.1}

(Nangia et al., 2021)

is ameliorated by Tbh^nM18

(Nangia et al., 2021)

is ameliorated by Nmdmc^UAS.Tag:HA

(Yu et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

ommatidium | adult stage, with Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Detailed Description

Statement

Reference

Expression of Hsap\MAPT^UAS.0N4R.cUa under the control of Scer\GAL4^GMR.PFa leads to rough eyes characterized by disorganized and fused ommatidia.

(Nangia et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-enhanceable by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-enhanceable by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Suppressed by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by Tbh^nM18

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible | partially by Tbh^{MI04010-TG4.1}

(Nangia et al., 2021)

NOT suppressed by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-suppressible by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-suppressible by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, non-enhanceable by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, non-enhanceable by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, non-enhanceable by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, non-enhanceable by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Suppressed by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by Tbh^nM18

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, suppressible by Tbh^nM18

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, suppressible | partially by Tbh^{MI04010-TG4.1}

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, suppressible | partially by Tbh^{MI04010-TG4.1}

(Nangia et al., 2021)

NOT suppressed by

Statement

Reference

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, non-suppressible by Tbh^rM6

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Hsap\MAPT^UAS.0N4R.cUa, Scer\GAL4^GMR.PFa has ommatidium | adult stage phenotype, non-suppressible by Tbh^UAS.cMa, Scer\GAL4^GMR.PFa

(Nangia et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

0N4R^II

(Keramidis et al., 2020)

Hsap\MAPT^UAS.0N4R.cUa

hTau^0N4R

(Keramidis et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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