FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fas2ΔmiR-210
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General Information
Symbol
Dmel\Fas2ΔmiR-210
Species
D. melanogaster
Name
FlyBase ID
FBal0353280
Feature type
allele
Associated gene
Dmel\Fas2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Niu et al., 2019)
Progenitor genotype
Cytology
Description

7bp deletion that removes the mir-210 binding motif within the Fas2 3'UTR.

(Niu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:4,134,726..4,134,732 [-]
Comment:

7bp deletion that removes the mir-210 binding motif within the Fas2 3'UTR.

Consequences_of_mutation:

regulatory mutation

(Niu et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fas2ΔmiR-210 mutant adults have significantly advanced evening peak circadian locomotor activity under light-dark conditions, compared to controls; period and rhythmicity under dark-dark are unaffected, compared to controls.

      (Niu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Fas2ΔmiR-210 has abnormal locomotor rhythm | adult stage | recessive phenotype, non-enhanceable by mir-210KO

      (Niu et al., 2019)
      NOT suppressed by
      Statement
      Reference

      Fas2ΔmiR-210 has abnormal locomotor rhythm | recessive | adult stage phenotype, non-suppressible by mir-210KO

      (Niu et al., 2019)
      NOT Enhancer of
      Statement
      Reference

      Fas2ΔmiR-210 is a non-enhancer of abnormal locomotor rhythm | adult stage | recessive phenotype of mir-210KO

      (Niu et al., 2019)
      NOT Suppressor of
      Statement
      Reference

      Fas2ΔmiR-210 is a non-suppressor of abnormal locomotor rhythm | recessive | adult stage phenotype of mir-210KO

      (Niu et al., 2019)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mir-210KO/+, Fas2ΔmiR-210/+ transheterozygous adults have significantly advanced evening peak circadian locomotor activity under light-dark conditions, compared to controls, unlike either single heterozygote.

      (Niu et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fas2ΔmiR-210
      (Niu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)