FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PI31S168A
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General Information
Symbol
Dmel\PI31S168A
Species
D. melanogaster
Name
FlyBase ID
FBal0353303
Feature type
allele
Associated gene
Dmel\PI31
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Liu et al., 2019)
Mutagen
CRISPR/Cas9
(Liu et al., 2019)
Progenitor genotype
Cytology
Description

A S168A amino acid substitution (non-phosphorylatable mutation) has been introduced into the endogenous PI31 locus.

(Liu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,967,898..11,967,898 [-]
Nucleotide change:

T11967898G

Reported nucleotide change:

A?C

Amino acid change:

S168A | PI31-PA; S168A | PI31-PB; S168A | PI31-PC; S168A | PI31-PD; S168A | PI31-PF

Reported amino acid change:

S168A

Comment:

The nucleotide change was reported on the noncoding strand.

(Liu et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PI31S168A homozygous larval motor neurons have significantly increased reversal of axonal transport direction of proteasomes, compared to controls.

      (Liu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PI31S168A
      (Liu et al., 2019)
      PI31S168A knockin
      (Liu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)