FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRα1attP
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General Information
Symbol
Dmel\nAChRα1attP
Species
D. melanogaster
Name
FlyBase ID
FBal0355476
Feature type
allele
Associated gene
Dmel\nAChRα1
Associated Insertion(s)
TI{TI}nAChRα1attP
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lu et al., 2022)
Mutagen
CRISPR/Cas9
(Rao and Deng, 2019.10.23)
gene targeting by homologous recombination
(Rao and Deng, 2019.10.23)
Progenitor genotype
Associated Insertion(s)
TI{TI}nAChRα1attP
Cytology
Description

An attP-Disc\RFP3xP3.cUa-loxP cassette replaces part of nAChRα1.

(Rao and Deng, 2019.10.23)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:24,401,668..24,402,113 [-]
Reported_genomic_loc:

3R_r6:24401668..24402113

Comment:

A attP-Disc\RFP3xP3.cUa-loxP cassette replaces the deleted genomic sequence.

(Rao and Deng, 2019.10.23)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nAChRα1attP adults exhibit a significant decrease in both day and night time sleep duration when compared to controls.

      (Deng et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ISODRZ12-CG5610
      (Rao and Deng, 2019.10.23)
      nAChR a 1-attP
      (Rao and Deng, 2019.10.23)
      nAChRα1attP
      (Lu et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)