FlyBase Allele Report: Htur\dR[WT.UAS.Tag:Mito(Unk),Tag:MYC]

General Information

Symbol

Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC}

Species

H. turkmenica

Name

FlyBase ID

FBal0358585

Feature type

allele

Associated gene

Htur\dR

Associated Insertion(s)

Carried in Construct

P{UAS-mito-dR.WT}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Imai et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-mito-dR.WT}

Cytology

Description

UASt regulates expression of a Delta-rhodopsin (Htur\dR) cDNA, fused to Tag:Mito(Unk) to target it to the mitochondrion, and tagged with Tag:MYC.

(Imai et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

light-regulated activity regulation tag

Tagged with

Tag:Mito(Unk)

mitochondrial protein localization tag

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 22

modeled by Chchd2^null

(Imai et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Amelioration of the Chchd2^null Parkinson's disease 22 model by Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} requires activation by light irradiation.

(Imai et al., 2019)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | light conditional, with Scer\GAL4^Ddc.PU

(Imai et al., 2019)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ddc.PU

(Imai et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^Ddc.PU-driven expression of Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} leads to a light-induced increase in flight activity.; there is also induction spontaneous locomotor activity.

(Imai et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor of abnormal flight | light conditional phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor of decreased cell number | adult stage phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU, Ucp4A^KK112027, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor | partially of decreased cell number | adult stage phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Chchd2^null

(Imai et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Ddc.PU, Ucp4A^KK112027, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a non-suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Chchd2^null

(Imai et al., 2019)

Other

Statement

Reference

Chchd2^null, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC}, Scer\GAL4^repo.PU has viable phenotype

(Imai et al., 2019)

Chchd2^null, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC}, Scer\GAL4^repo.PU has short lived | light conditional phenotype

(Imai et al., 2019)

Chchd2^null, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC}, Scer\GAL4^nrv2.PU has viable phenotype

(Imai et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^Ddc.PU, Ucp4A^KK112027, Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor | partially of dopaminergic PPM2 neuron | decreased number phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^da.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor | light conditional of indirect flight muscle cell phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^da.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor | light conditional of mitochondrial crista | adult stage phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor of dopaminergic PPL1 neuron | decreased number phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor of dopaminergic PPM2 neuron | decreased number phenotype of Chchd2^null

(Imai et al., 2019)

Scer\GAL4^Ddc.PU/Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC} is a suppressor of dopaminergic PPM3 neuron | decreased number phenotype of Chchd2^null

(Imai et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Htur\dR^{WT.UAS.Tag:Mito(Unk),Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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