FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\BbdΔ
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General Information
Symbol
Dmel\BbdΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0358825
Feature type
allele
Associated gene
Dmel\Bbd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lin et al., 2019)
Mutagen
CRISPR/Cas9
(Lin et al., 2019)
Progenitor genotype
Cytology
Description

Deletion of 1,906 bp encompassing the annotated Bbd transcriptional unit.

(Lin et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:20,534,248..20,536,154 [+]
Comment:

The CRISPR deletion was engineered to remove the region from 2R:20534248..20536154 .

(Lin et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BbdΔ homozygous adults are not morphologically different than controls.

      BbdΔ homozygous adults exhibit increased mortality as a result of Candida glabrata, Fusarium oxysporum, Enterococcus faecalis (alive or heat killed) or heat-killed Micrococcus luteus but not Enterobacter cloacae infection when compared to controls.

      The pathogen loads of early deaths for BbdΔ homozygous adults are not significantly different than controls. The pathogen load of late BbdΔ homozygous fly deaths is significantly lower than that of the early-death BbdΔ homozygotes and controls, and also significantly higher than that of live controls 120 hours post infection.

      (Lin et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Myd88kra-1 or Df(2R)BomΔ55C suppresses the increased mortality phenotype of BbdΔ homozygous adults infected with either heat-killed Enterococcus faecalis or heat-killed Micrococcus luteus.

      (Lin et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bbd mutants
      (Lou et al., 2026)
      BbdΔ
      Δbbd
      (Lin et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)