FB2025_05 , released December 11, 2025
Allele: Dmel\Myd88kra-1
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General Information
Symbol
Dmel\Myd88kra-1
Species
D. melanogaster
Name
FlyBase ID
FBal0144726
Feature type
allele
Associated gene
Dmel\Myd88
Associated Insertion(s)
Carried in Construct
Also Known As
MyD88kra1, dMyd88kra1, kra1
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Myd88EP2535
    (Charatsi et al., 2003)
    Cytology
    Description

    Imprecise excision for the insertion in Myd88EP2535 removes the 2257bp of the Myd88 gene including almost all of the first exon.

    (Charatsi et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2R:9,306,311..9,308,568 [-]
    Comment:

    Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Mutation is a deletion induced by P element imprecise excision using P{EP}Myd88EP2535.

    (Charatsi et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Myd88kra-1 flies show increased mortality to systemic infection with F. graminearum, F. verticillioides, A. parasiticus, A. flavus, A. fumigatus, B. cinerea and N. crassa when compared to controls.

        (Cohen et al., 2020)

        Myd88kra-1 adults do not exhibit any changes in mortality as a result of heat-killed Enterococcus faecalis or heat-killed Micrococcus luteus infection when compared to controls

        (Lin et al., 2019)

        Compared to wild type controls, adult Myd88kra-1 flies are much more susceptible to septic infection by the Enterococcus faecalis bacterium, the yeast Candida glabrata or the filamentous fungus Fusarium oxysporum. In contrast, septic infection with the Enterobacter cloacae bacterium has no significant effect on survival.

        Myd88kra-1 flies show an elevated bacterial load above that of control levels during the course of Enterococcus faecalis infection, indicative of a defect in infection resistance.

        (Clemmons et al., 2015)

        Embryos laid by homozygous Myd88kra-1 or Myd88kra-56/Myd88kra-1 mothers fail to gastrulate properly and die as hollow tubes of dorsal cuticle. The Filzkorper is present in these embryos.

        (Charatsi et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Suppressor of
        Statement
        Reference

        Myd88kra-1 is a suppressor of abnormal immune response | adult stage phenotype of BbdΔ

        (Lin et al., 2019)

        Myd88kra-1 is a suppressor of increased mortality | adult stage phenotype of BbdΔ

        (Lin et al., 2019)
        NOT Suppressor of
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        Myd88kra-1 has embryonic epidermis | ventral phenotype, non-enhanceable by Tl3

        (Charatsi et al., 2003)
        Suppressed by
        Statement
        Reference

        Myd88kra-1 has embryonic epidermis | ventral phenotype, suppressible by tor::tubt4021t

        (Charatsi et al., 2003)
        NOT Enhancer of
        Suppressor of
        Statement
        Reference

        Myd88kra-1 is a suppressor of embryonic dorsal epidermis phenotype of Tl3

        (Charatsi et al., 2003)
        NOT Suppressor of
        Other
        Statement
        Reference

        Myd88kra-1, Tl3 has embryonic epidermis | ventral phenotype

        (Charatsi et al., 2003)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Myd88kra-1 suppresses the increased mortality phenotype of BbdΔ homozygous adults infected with either heat-killed Enterococcus faecalis or heat-killed Micrococcus luteus.

        (Lin et al., 2019)

        Embryos laid by homozygous Myd88kra-1 and Tl3/+ mothers show a completely dorsalised phenotype. When tor::tubt4021t is injected into embryos laid by snkunspecified mothers, significant rescue of the dorsalised phenotype is seen. Some ventrolateral pattern elements are seen, such as ventral denticle belts and Filzkorper, which are never seen in Myd88kra-1 mutant embryos.

        (Charatsi et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        MyD88kra1
        (Cohen et al., 2020, Lin et al., 2019, Clemmons et al., 2015)
        Myd88kra-1
        dMyD88kra1
        (Iwashita et al., 2020)
        dMyd88kra1
        (Kanoh et al., 2021, Kenmoku et al., 2017)
        kra1
        (Sun et al., 2004, Charatsi et al., 2003)
        Name Synonyms
        Secondary FlyBase IDs
          References (8)