FB2026_02 , released June 18, 2026
Allele: Dmel\snoRNA:Ψ28S-1153UAS.cSa
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General Information
Symbol
Dmel\snoRNA:Ψ28S-1153UAS.cSa
Species
D. melanogaster
Name
UAS construct a of Soule
FlyBase ID
FBal0358997
Feature type
allele
Associated gene
Dmel\snoRNA:Ψ28S-1153
Associated Insertion(s)
Carried in Construct
P{UAS-snoRNA:Ψ28S-1153.S}
Also Known As
UAS-jou
Key Links
Transgenic product class
wild_type
(Soulé et al., 2020)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Soulé et al., 2020)
Mutagen
in vitro construct
(Soulé et al., 2020)
Progenitor genotype
Carried in construct
P{UAS-snoRNA:Ψ28S-1153.S}
Cytology
Description

UAS regulates expression of the 148 bp snoRNA:Ψ28S-1153 gene.

(Soulé et al., 2020)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
snoRNA:Ψ28S-1153
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In an otherwise control background, constitutive expression of snoRNA:Ψ28S-1153UAS.cSa under the control of either Scer\GAL4NP0001 or Scer\GAL4mex1.2.1 induces an increase in female lifespan, as compared to controls. Adulthood-only expression under the control of Scer\GAL4mex1.GS (induced by feeding with RU486) also induces an increase in female lifespan, as well as an increase in female gut ploidy/endoreplication, as compared to controls.

      Constitutive expression of snoRNA:Ψ28S-1153UAS.cSa under the control of either Scer\GAL4NP0001 or Scer\GAL4mex1.2.1 rescues both the decreased lifespan and the increased numbers of enterocytes in the gut (in both 7 days old and40 days old individuals) exhibited by Df(2R)F4 homozygous females. Adulthood-only expression under the control of Scer\GAL4mex1.GS (induced by feeding with RU486) also rescues lifespan. Constitutive expression under the control of Scer\GAL4mex1.2.1 also rescues the decreased gut ploidy/endoreplication of Df(2R)F4 homozygous females. Constitutive expression under the control of Scer\GAL4NP0001 also rescues the decreased resistance to desiccation of Df(2R)F4 homozygous females.

      (Soulé et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      snoRNA:Ψ28S-1153UAS.cSa
      Name Synonyms
      UAS construct a of Soule
      Secondary FlyBase IDs
        References (2)