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Citation
Soulé, S., Mellottée, L., Arab, A., Chen, C., Martin, J.R. (2020). Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila.  Nat. Commun. 11(1): 987.
FlyBase ID
FBrf0244921
Publication Type
Research paper
Abstract

Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its overexpression in wild-type increases lifespan. Jouvence is required in enterocytes. In mutant, the epithelium of the gut presents more hyperplasia, while the overexpression of jouvence prevents it. Molecularly, the mutant lack pseudouridylation on 18S and 28S-rRNA, a function rescued by targeted expression of jouvence in the gut. A transcriptomic analysis performed from the gut reveals that several genes are either up- or down-regulated, while restoring the mRNA level of two genes (ninaD or CG6296) rescue the longevity. Since snoRNAs are structurally and functionally well conserved throughout evolution, we identified putative jouvence orthologue in mammals including humans, suggesting that its function in longevity could be conserved.

PubMed ID
PubMed Central ID
PMC7033134 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location of Df(2R)F4 and snoRNAs rescue fragment.
Martin, 2020.5.19, Location of Df(2R)F4 and snoRNAs rescue fragment. [FBrf0245695]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference