FlyBase Allele Report: Dmel\tau[hTau.1N4R-V337M]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\tau^{hTau.1N4R-V337M}

General Information

Symbol

Dmel\tau^{hTau.1N4R-V337M}

Species

D. melanogaster

Name

FlyBase ID

FBal0360601

Feature type

allele

Associated gene

Associated Insertion(s)

TI{TI}tau^{hTau.1N4R-V337M}

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

(Cassar et al., 2020)

gene targeting by homologous recombination

(Cassar et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}tau^{hTau.1N4R-V337M}

Cytology

Description

A cDNA encoding the Hsap\MAPT 1N4R isoform, mutated to carry the V337M amino acid replacement (a pathogenic variant associated with FTDP-17, Frontotemporal Dementia with Parkinsonism linked to chromosome 17), has been knocked in to the endogenous tau locus (the human coding sequence replaces the endogenous Drosophila coding sequence). A Disc\RFP^{DsRed(T1).3xP3.cHa} marker has also been inserted, downstream of the inserted Hsap\MAPT coding sequence.

(Cassar et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of frontotemporal dementia

CEA

(Law et al., 2022, Cassar et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has abnormal circadian rhythm | recessive | progressive phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has abnormal locomotor behavior | recessive | adult stage | progressive phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has abnormal neuroanatomy | dominant | adult stage | progressive phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has decreased efficacy of short-term memory | dominant | adult stage | progressive phenotype

(Law et al., 2022)

Phenotype Manifest In

Other

Statement

Reference

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has l-LNv neuron phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has adult s-LNv neuron phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has medulla | adult stage phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has axon | adult stage phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has microtubule | adult stage phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has adult deutocerebrum phenotype

(Law et al., 2022)

Hsap\MAPT^{tau.1N4R-V337M}, tau^{hTau.1N4R-V337M} has axon terminus | adult stage phenotype

(Law et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tau^V337M

(Curley et al., 2024)

tau^{hTau.1N4R-V337M}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections