FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hyls156
Open Close
General Information
Symbol
Dmel\Hyls156
Species
D. melanogaster
Name
FlyBase ID
FBal0360802
Feature type
allele
Associated gene
Dmel\Hyls1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hou et al., 2020)
Mutagen
CRISPR/Cas9
(Hou et al., 2020)
Progenitor genotype
Cytology
Description

Deletion of most (206 bp) of the second exon of Hyls1 coupled with an insertion an extra 10-bp nucleotides, leading to a predicted reading frame shift. Only the first 38 amino acids of the very N-terminus are predicted to be translated followed shortly by a de novo stop codon. chif lies in the intron between exon 1 and exon 2 of Hyls1 and Hyls156 deletes the 30-aa C-terminus specific to chif-RA. This lesion in chif is designated chif56. The chif-RB and chif-RD isoforms are unaffected by this lesion and, because these isoforms are fully functional, the chif56 mutant should not affect chif function.

(Hou et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
2L:16,343,085..16,343,290 [-]
Comment:

A 206bp deletion and 10bp insertion in the second exon of Hyls1. The deletion also affects the chif-RA transcript.

Inserted_sequence:

NNNNNNNNNN

(Hou et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Hyls156 homozygous scolopidium one of the axonemes is missing.

      Hyls156 homozygous larvae exhibit reduced touch sensitivity while Hyls156 homozygous adults exhibit abnormal locomotor behavior (climbing defect) and abnormal chemosensitive behavior (defects in attraction to grape juice).

      Hyls156 homozygous spermatocytes exhibit shorter centrioles. Hyls156 homozygous spermatids exhibit a decrease in their number, loss of bundled organization, loss of atypical centrioles and incomplete and broken axonemal.

      Embryos fathered by Hyls156 homozygotes exhibit developmental delay and arrest at the early cleavage stage.

      (Hou et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Hyls156 is rescued by Hyls1Ub.GFP

      (Hou et al., 2020)
      Partially rescued by

      Hyls156 is partially rescued by Scer\GAL4elav-C155/Hyls1UAS.GFP

      (Hou et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hyls156
      hyls156
      (Hou et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)