FlyBase Allele Report: Dmel\Cisd[2-1]

General Information

Symbol

Dmel\Cisd^2-1

Species

D. melanogaster

Name

FlyBase ID

FBal0360878

Feature type

allele

Associated gene

Dmel\Cisd

Associated Insertion(s)

TI{TI}Cisd^2-1

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2020)

Mutagen

CRISPR/Cas9

(Chen et al., 2020)

gene targeting by homologous recombination

(Chen et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}Cisd^2-1

Cytology

Description

Part of the Cisd2 coding sequence has been deleted. A Disc\RFP^3xP3.cUa marker has been inserted in place of the deleted sequence.

(Chen et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Chen et al., 2020)

decreased rate of adult locomotory behavior | progressive

(Martinez et al., 2024)

long lived

(Chen et al., 2020)

short lived

(Martinez et al., 2024)

Phenotype Manifest In

flight muscle

(Martinez et al., 2024)

flight muscle cell | adult stage

(Chen et al., 2020)

mitochondrion

(Martinez et al., 2024)

mitochondrion | adult stage

(Chen et al., 2020)

Detailed Description

Statement

Reference

Cisd2^2-1 homozygous adults exhibit smaller and rounder mitochondria in flight muscles. 3-weeks-old adult show increased climbing ability compared to controls.

(Chen et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Cisd^2-1 has mitochondrion | adult stage phenotype, suppressible | partially by Scer\GAL4^Mef2.247/Mmus\Cisd1::Mmus\Cisd2^UAS.Tag:HA

(Chen et al., 2020)

Cisd^2-1 has flight muscle cell | adult stage phenotype, suppressible | partially by Scer\GAL4^Mef2.247/Mmus\Cisd1::Mmus\Cisd2^UAS.Tag:HA

(Chen et al., 2020)

NOT suppressed by

Statement

Reference

Cisd^2-1 has flight muscle cell | adult stage phenotype, non-suppressible by Scer\GAL4^Mef2.247/Mmus\Cisd1^UAS.Tag:HA

(Chen et al., 2020)

Cisd^2-1 has mitochondrion | adult stage phenotype, non-suppressible by Scer\GAL4^Mef2.247/Mmus\Cisd1^UAS.Tag:HA

(Chen et al., 2020)

Cisd^2-1 has flight muscle cell | adult stage phenotype, non-suppressible by Mmus\Cisd2^UAS.Tag:HA/Scer\GAL4^Mef2.247

(Chen et al., 2020)

Cisd^2-1 has mitochondrion | adult stage phenotype, non-suppressible by Mmus\Cisd2^UAS.Tag:HA/Scer\GAL4^Mef2.247

(Chen et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Cisd KO

(Martinez et al., 2024)

Cisd2^2-1

Cisd^2-1

Dosmit-2-1

(Chen et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close