FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MiroA20V.UAS.Tag:MYC
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General Information
Symbol
Dmel\MiroA20V.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0360937
Feature type
allele
Associated gene
Dmel\Miro
Associated Insertion(s)
Carried in Construct
P{UAS-Miro.A20V.Myc}
Key Links
Transgenic product class
missense_variant
(Babic et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Babic et al., 2015)
Mutagen
in vitro construct
(Babic et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Miro.A20V.Myc}
Cytology
Description

UASt regulatory sequences drive expression of a Miro-RC transcript that has been mutated to carry a A20V amino acid substitution (mutation in the N-terminal GTPase domain). The coding sequence is tagged with Tag:MYC.

(Babic et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Miro
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neuromuscular disease
      modeled by Hsap\TRPV4R269C.UAS.BID
      (Woolums et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individuals expressing MiroA20V.UAS.Tag:MYC under the control of Scer\GAL4CCAP.PU fail to expand their wings after eclosion.

      Expressing MiroA20V.UAS.Tag:MYC under the control of Scer\GAL4ppk.PU leads to wandering third instar larvae showing a marked loss of C4da neuron axonal projections into the ventral nerve cord.

      (Woolums et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Enhancer of
      Phenotype Manifest In
      NOT Enhanced by
      NOT suppressed by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MiroA20V.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)