FlyBase Allele Report: Dmel\Miro[E234K.E354K.UAS]

General Information

Symbol

Dmel\Miro^{E234K.E354K.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0361635

Feature type

allele

Associated gene

Dmel\Miro

Associated Insertion(s)

Carried in Construct

P{UAS-Miro.E234K.E354K}

Key Links

Transgenic product class

missense_variant

(Woolums et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Woolums et al., 2020)

Mutagen

in vitro construct

(Woolums et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-Miro.E234K.E354K}

Cytology

Description

UAS regulatory sequences drive expression of Miro that has been mutated to carry E234K and E354K amino acid replacements (this results in a protein that is unable to bind Ca[2+]).

(Woolums et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Miro

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-enhancer of abnormal neuroanatomy | larval stage | progressive phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

NOT Suppressor of

Statement

Reference

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-suppressor of abnormal neuroanatomy | larval stage | progressive phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-enhancer of larval multidendritic class IV neuron | wandering third instar larval stage phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-enhancer of axon | wandering third instar larval stage phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

NOT Suppressor of

Statement

Reference

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-suppressor of larval multidendritic class IV neuron | wandering third instar larval stage phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

Miro^{E234K.E354K.UAS}, Scer\GAL4^ppk.PU is a non-suppressor of axon | wandering third instar larval stage phenotype of Hsap\TRPV4^R269C.UAS, Scer\GAL4^ppk.PU

(Woolums et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Miro^{E234K.E354K.UAS}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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