FlyBase Allele Report: Dmel\PTPMT1[mut3]

General Information

Symbol

Dmel\PTPMT1^mut3

Species

D. melanogaster

Name

FlyBase ID

FBal0362177

Feature type

allele

Associated gene

Dmel\PTPMT1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Papakyrikos et al., 2020)

Progenitor genotype

Cytology

Description

Mutation (c.12 + 82delT and c487delA) within PTPMT1.

(Papakyrikos et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:23,758,610..23,758,610 [+]

Comment:

A 1bp deletion that falls within the 5' UTR of PTPMT1-RA and in an intron of PTPMT1-RB. One of two 1bp deletions in mutant.

(Papakyrikos et al., 2020)

deletion

3R:23,759,370..23,759,370 [+]

Comment:

A 1bp deletion within the final coding exon of PTPMT1. One of two 1bp deletions in mutant.

(Papakyrikos et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Papakyrikos et al., 2020)

lethal (with Df(3R)BSC490)

(Papakyrikos et al., 2020)

lethal (with Df(3R)Exel9013)

(Papakyrikos et al., 2020)

some die during embryonic stage

(Papakyrikos et al., 2020)

some die during embryonic stage (with Df(3R)BSC490)

(Papakyrikos et al., 2020)

some die during larval stage

(Papakyrikos et al., 2020)

some die during larval stage (with Df(3R)BSC490)

(Papakyrikos et al., 2020)

Phenotype Manifest In

embryonic/larval tracheal section | third instar larval stage

(Papakyrikos et al., 2020)

Detailed Description

Statement

Reference

PTPMT1^mut3/PTPMT1^mut3 third instar larvae exhibit tracheal blackening.

(Papakyrikos et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PTPMT1^mut3

dPTPMT1^mut3

(Papakyrikos et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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