FB2026_02 , released June 18, 2026
Allele: Dmel\Gαohumanized
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General Information
Symbol
Dmel\Gαohumanized
Species
D. melanogaster
Name
FlyBase ID
FBal0364104
Feature type
allele
Associated gene
Dmel\Gαo
Associated Insertion(s)
TI{TI}Gαohumanized
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Savitsky et al., 2020)
gene targeting by homologous recombination
(Savitsky et al., 2020)
Progenitor genotype
TI{TI}Gαoh23ex4aa
(Savitsky et al., 2020)
Associated Insertion(s)
TI{TI}Gαohumanized
Cytology
Description

The coding sequence of the endogenous Gαo locus has been almost completely 'humanized'; all but 5 of the codons that differ between Gαo and Hsap\GNAO1 have been changed to encode the human amino acid residue (in total, 49 amino acid residues have been changed).

(Savitsky et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Gαohumanized
      (Savitsky et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)