FB2026_02 , released June 18, 2026
Allele: Dmel\Hsp60CKO
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General Information
Symbol
Dmel\Hsp60CKO
Species
D. melanogaster
Name
FlyBase ID
FBal0365237
Feature type
allele
Associated gene
Dmel\Hsp60C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Gao et al., 2020)
Progenitor genotype
Cytology
Description

100bp deletion ( 2L:5669022..5669121 , release 6 genome) and GTA to TGT mutation ( 2L:5669019..5669021 ) (revision of data in FBrf0247226).

(Xu, 2021.8.21)

Deletion within the Hsp60C coding sequence, resulting in the formation of a premature stop codon.

(Gao et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:5,669,022..5,669,121 [+]
Comment:

A 97bp deletion within the Hsp60C coding sequence, resulting in early translation termination.

Inserted_sequence:

GTA

(Xu, 2021.8.21)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hsp60CKO homozygotes do not show mature sperm in the seminal vesicle; individualization complexes are asynchronous at the late canoe spermatogenesis stage.

      (Gao et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsp60CKO/Hsp60C[+] is a suppressor | partially of male semi-sterile | progressive phenotype of bolintron3.KO

      (Gao et al., 2020)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsp60C KO
      (Gao et al., 2020)
      Hsp60CKO
      Name Synonyms
      Secondary FlyBase IDs
        References (2)