FlyBase Allele Report: Dmel\snRNA:U12[Δ]

General Information

Symbol

Dmel\snRNA:U12^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0365406

Feature type

allele

Associated gene

Dmel\snRNA:U12

Associated Insertion(s)

Carried in Construct

Also Known As

U12^Δ

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Li et al., 2020)

Mutagen

CRISPR/Cas9

(Li et al., 2020)

Progenitor genotype

Cytology

Description

Deletion that removes the entire snRNA:U12 snRNA sequence (deletion extends from -2 to +293 relative to the transcription start site).

(Li et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:16,653,769..16,654,006 [+]

Comment:

A deletion of snRNA:U12 reported as mapping to 3L:16 ,653,769..16,654,006.

(Li et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage

(Li et al., 2020)

abnormal locomotor behavior | larval stage (with Df(2L)ED629)

(Li et al., 2020)

abnormal neuroanatomy | larval stage

(Li et al., 2020)

decreased rate of larval locomotory behavior

(Li et al., 2024)

lethal - all die before end of pupal stage

(Li et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Li et al., 2020)

embryonic/larval neuromuscular junction | larval stage (with Df(2L)ED629)

(Li et al., 2020)

NMJ bouton | decreased number

(Li et al., 2024)

NMJ bouton | decreased number | larval stage

(Li et al., 2020)

NMJ bouton | decreased number | larval stage (with Df(2L)ED629)

(Li et al., 2020)

Detailed Description

Statement

Reference

snRNA:U12^Δ homozygous and snRNA:U12^Δ/Df(3L)BSC561 larvae show decreased locomotion and their neuromuscular junctions are abnormal, with fewer boutons, compared to controls.

(Li et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

snRNA:U12^Δ has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Pcyt2^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Fas3^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Zmynd10^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Pcyt2^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Zmynd10^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Fas3^UAS.cLa

(Li et al., 2020)

NOT suppressed by

Statement

Reference

snRNA:U12^Δ has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/CG16984^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/galectin^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal locomotor behavior | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/CG16984^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has abnormal locomotor behavior | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/galectin^UAS.cLa

(Li et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

snRNA:U12^Δ has NMJ bouton | larval stage | decreased number phenotype, suppressible | partially by Scer\GAL4^elav-C155/Zmynd10^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Pcyt2^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Zmynd10^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Fas3^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has NMJ bouton | larval stage | decreased number phenotype, suppressible | partially by Scer\GAL4^elav-C155/Pcyt2^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has NMJ bouton | larval stage | decreased number phenotype, suppressible | partially by Scer\GAL4^elav-C155/Fas3^UAS.cLa

(Li et al., 2020)

NOT suppressed by

Statement

Reference

snRNA:U12^Δ has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by Scer\GAL4^elav-C155/CG16984^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has NMJ bouton | larval stage | decreased number phenotype, non-suppressible by Scer\GAL4^elav-C155/galectin^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/CG16984^UAS.cLa

(Li et al., 2020)

snRNA:U12^Δ has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/galectin^UAS.cLa

(Li et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

U12^Δ

(Li et al., 2024, Li et al., 2020)

snRNA:U12^Δ

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections