FlyBase Allele Report: Hsap\RPS12[UAS.cKa]

General Information

Symbol

Hsap\RPS12^UAS.cKa

Species

H. sapiens

Name

UAS construct a of Katanaev

FlyBase ID

FBal0365598

Feature type

allele

Associated gene

Hsap\RPS12

Associated Insertion(s)

Carried in Construct

M{UAS-hRPS12.K}

Key Links

Transgenic product class

wild_type

(Katanaev et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Katanaev et al., 2020)

Mutagen

in vitro construct

(Katanaev et al., 2020)

Progenitor genotype

Carried in construct

M{UAS-hRPS12.K}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\RPS12.

(Katanaev et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\RPS12

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

decreased size | adult stage, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Phenotype Manifest In

cornea, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

eye, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

ommatidium, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

pigment cell | decreased number, with Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Detailed Description

Statement

Reference

Expressing Hsap\RPS12^UAS.cKa under the control of Scer\GAL4^GMR.PU induces a small, glossy eye phenotype; there is ommatidial degeneration and fusion, and loss of the regular corneal nipple arrays.

(Katanaev et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype, suppressible | partially by Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by RpS12^s2783/RpS12[+]

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype, suppressible | partially by RpS12^s2783/RpS12[+]

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by RpS12^KK115942, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype, suppressible | partially by RpS12^KK115942, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by RpS12^s2783/RpS12[+]

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by RpS12^KK115942, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Axn^ΔRGS.UAS, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Hsap\RPS12^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by wg^GD5007, Scer\GAL4^GMR.PU

(Katanaev et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\RPS12^UAS.cKa

Name Synonyms

UAS construct a of Katanaev

Secondary FlyBase IDs

References (1)

Report Sections

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