FlyBase Allele Report: Dmel\ZnT63C[2]

General Information

Symbol

Dmel\ZnT63C²

Species

D. melanogaster

Name

FlyBase ID

FBal0365695

Feature type

allele

Associated gene

Dmel\ZnT63C

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Wang et al., 2020)

Progenitor genotype

Cytology

Description

1bp deletion within within the ZnT63C coding sequence; predicted to result in a frameshift followed by a stop codon 12 residues later.

(Wang et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:3,312,176..3,312,176 [+]

Comment:

1bp deletion within the ZnT63C coding sequence; predicted to result in a frameshift mutation and early translation termination after the addition of 12 novel amino acids.

(Wang et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Wang et al., 2020)

majority die during larval stage

(Wang et al., 2020)

some die during P-stage

(Wang et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ZnT63C² has increased mortality during development phenotype, suppressible by Hsap\SLC30A1^UAS.cWa/Scer\GAL4^da.PU

(Wang et al., 2020)

ZnT63C² has increased mortality during development phenotype, suppressible by Hsap\SLC30A1^UAS.cWa/Scer\GAL4^NP3084

(Wang et al., 2020)

ZnT63C² has increased mortality during development phenotype, suppressible | partially by Hsap\SLC30A1^UAS.cWa/Scer\GAL4^NP2375

(Wang et al., 2020)

NOT suppressed by

Statement

Reference

ZnT63C² has increased mortality during development phenotype, non-suppressible by Scer\GAL4^drm.PU/Hsap\SLC30A1^UAS.cWa

(Wang et al., 2020)

ZnT63C² has increased mortality during development phenotype, non-suppressible by Hsap\SLC30A1^UAS.cWa/Scer\GAL4^ninaD.PW

(Wang et al., 2020)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ZnT63C²

dZnT1*-2

(Wang et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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