FB2026_02 , released June 18, 2026
Allele: Dmel\l(3)neo38CRISPR
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General Information
Symbol
Dmel\l(3)neo38CRISPR
Species
D. melanogaster
Name
FlyBase ID
FBal0365772
Feature type
allele
Associated gene
Dmel\l(3)neo38
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Reddington et al., 2020)
Mutagen
CRISPR/Cas9
(Reddington et al., 2020)
Progenitor genotype
Cytology
Description

Five of the six coding exons of l(3)neo38 have been deleted (the deletion removes the zinc-finger domain).

(Reddington et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:11,768,692..11,771,678 [-]
Inserted_sequence:

CC

Comment:

Most of the coding sequence of l(3)neo38 has been deleted. CC is present at the site of the deletion.

(Furlong, 2021.4.12)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      l(3)neo38CRISPR homozygous larvae exhibit smaller and less branched neuromuscular junctions.

      l(3)neo38CRISPR homozygous adults exhibit severely reduced motility, are barely able to walk and unable to fly (with a wings-up phenotype).

      (Reddington et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      l(3)neo38CRISPR
      (Reddington et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)