FlyBase Allele Report: Dmel\msl-1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\msl-1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0367159

Feature type

allele

Associated gene

Dmel\msl-1

Associated Insertion(s)

Carried in Construct

P{UAS-msl-1.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-msl-1.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi line that targets msl-1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

msl-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

abnormal size | adult stage | male limited, with Scer\GAL4^nub-AC-62

(Clemente-Ruiz et al., 2016)

increased cell death | larval stage | male limited, with Scer\GAL4^e22c

(Clemente-Ruiz et al., 2016)

visible | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

visible | male limited, with Scer\GAL4^nub-AC-62

(Clemente-Ruiz et al., 2016)

Phenotype Manifest In

eye | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

wing | male limited, with Scer\GAL4^nub-AC-62

(Clemente-Ruiz et al., 2016)

wing disc posterior compartment, with Scer\GAL4^e22c

(Clemente-Ruiz et al., 2016)

Detailed Description

Statement

Reference

The expression of msl-1^{dsRNA.UAS.cUa} leads to severely smaller wings (under the control of Scer\GAL4^nub-AC-62 ) and eyes (under the control of Scer\GAL4^ey.PH) and leads to a severe increase in apoptosis (TUNEL assay) in the wing disc posterior compartment (under the control of Scer\GAL4^e22c), as compared to controls; these defects are only observed in males.

(Clemente-Ruiz et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^e22c, msl-1^RNAi.UAS.cUa has increased cell death | larval stage | male limited phenotype, enhanceable by lic^RNAi.UAS.cUa/Scer\GAL4^e22c

(Clemente-Ruiz et al., 2016)

Suppressed by