FB2026_02 , released June 18, 2026
Allele: Dmel\SvipRR.UAS.mCherry
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General Information
Symbol
Dmel\SvipRR.UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0367209
Feature type
allele
Associated gene
Dmel\Svip
Associated Insertion(s)
Carried in Construct
P{UAS-Svip.RR.mCherry}
Key Links
Transgenic product class
missense_variant
(Johnson et al., 2021)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Johnson et al., 2021)
Mutagen
in vitro construct
(Johnson et al., 2021)
Progenitor genotype
Carried in construct
P{UAS-Svip.RR.mCherry}
Cytology
Description

UAS regulatory sequences drive expression of Svip (sequence from cDNA clone GH02734) that has been mutated to contain two amino acid substitutions (R24A and R25A) in the VCP-interaction motif. The coding sequence is tagged with mCherry.

(Johnson et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Svip
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  syndrome
      CEA
      (Johnson et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing SvipRR.UAS.mCherry under the control of Scer\GAL4Mhc.PU show decreased climbing activity; abdominal muscles show altered mitochondria with apparent vacuoles.

      (Johnson et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SvipRR.UAS.mCherry/Scer\GAL4Mhc.PU fails to rescue SvipKO

      (Johnson et al., 2021)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SvipRR.UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)