FlyBase Allele Report: Dmel\DIP-α[null1]

General Information

Symbol

Dmel\DIP-α^null1

Species

D. melanogaster

Name

FlyBase ID

FBal0368920

Feature type

allele

Associated gene

Dmel\DIP-α

Associated Insertion(s)

Carried in Construct

Also Known As

DIP-α^1-178

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Xu et al., 2018)

Progenitor genotype

Cytology

Description

50bp deletion within DIP-α.

(Xu et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:3,522,238..3,522,287 [-]

Comment:

50bp deletion within DIP-α.

(Xu et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Xu et al., 2022)

abnormal neuroanatomy | adult stage (with DIP-α^-20F)

(Xu et al., 2022)

abnormal neuroanatomy | adult stage (with DIP-α^-50F)

(Xu et al., 2022)

decreased cell number | adult stage

(Xu et al., 2022)

decreased cell number | adult stage (with DIP-α^-20F)

(Xu et al., 2022)

decreased cell number | adult stage (with DIP-α^-50F)

(Xu et al., 2022)

Phenotype Manifest In

distal medullary amacrine neuron Dm1 | adult stage | decreased number

(Xu et al., 2022)

distal medullary amacrine neuron Dm4 | adult stage | decreased number

(Xu et al., 2022)

distal medullary amacrine neuron Dm4 | adult stage | decreased number (with DIP-α^-20F)

(Xu et al., 2022)

distal medullary amacrine neuron Dm4 | adult stage | decreased number (with DIP-α^-50F)

(Xu et al., 2022)

distal medullary amacrine neuron Dm12 | adult stage (with DIP-α^-20F)

(Xu et al., 2022)

distal medullary amacrine neuron Dm12 | adult stage | decreased number

(Xu et al., 2022)

distal medullary amacrine neuron Dm12 | adult stage | decreased number (with DIP-α^-50F)

(Xu et al., 2022)

neuron projection | adult stage

(Xu et al., 2022)

neuron projection | adult stage (with DIP-α^-20F)

(Xu et al., 2022)

neuron projection | adult stage (with DIP-α^-50F)

(Xu et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

DIP-α^null1/DIP-α^-50F is an enhancer of decreased cell number | adult stage phenotype of dpr6^null

(Xu et al., 2022)

DIP-α^null1/DIP-α^-50F is an enhancer of abnormal neuroanatomy | adult stage phenotype of dpr6^null

(Xu et al., 2022)

DIP-α^null1/DIP-α^-20F is an enhancer of abnormal neuroanatomy | adult stage phenotype of dpr6^null

(Xu et al., 2022)

NOT Enhancer of

Statement

Reference

DIP-α^null1/DIP-α^-20F is a non-enhancer of decreased cell number | adult stage phenotype of dpr6^null

(Xu et al., 2022)

Phenotype Manifest In

Enhancer of

Statement

Reference

DIP-α^null1/DIP-α^-50F is an enhancer of distal medullary amacrine neuron Dm12 | adult stage | decreased number phenotype of dpr6^null

(Xu et al., 2022)

DIP-α^null1/DIP-α^-50F is an enhancer of neuron projection | adult stage phenotype of dpr6^null

(Xu et al., 2022)

DIP-α^null1/DIP-α^-20F is an enhancer of neuron projection | adult stage phenotype of dpr6^null

(Xu et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DIP-α^1-178

(Ashley et al., 2019, Cheng et al., 2019)

DIP-α^CR

(Wang et al., 2024)

DIP-α^null1

(Xu et al., 2022, Xu et al., 2018)

DIP-α^null

(Wang et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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